Description
| Product Name: | Human PCNP Recombinant Protein |
| Product Code: | RPPB4201 |
| Size: | 20µg |
| Species: | Human |
| Target: | PCNP |
| Synonyms: | PEST proteolytic signal-containing nuclear protein, PCNP, PEST-containing nuclear protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PCNP protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMADGKA GDEKPEKSQR AGAAGGPEEE AEKPVKTKTV SSSNGGESSS RSAEKRSAEE EAADLPTKPT KISKFGFAIG SQTTKKASAI SIKLGSSKPK ETVPTLAPKT LSVAAAFNED EDSEPEEMPP EAKMRMKNIG RDTPTSAGPN SFNKGKHGFS DNQKLWERNI KSHLGNVHDQ DN |
PEST proteolytic signal containing nuclear protein (PCNP) is a nuclear protein involved in cell cycle regulation and tumorigenesis. The PCNP protein is ubiquitinated post-translationally by NIRF (an ubiquitin ligase). The PCNP exists as 3 isoforms produced by alternative splicing events.
PCNP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 202 amino acids (1-178 a.a.) and having a molecular mass of 21.5kDa.PCNP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PCNP: a nuclear protein that may be involved in cell cycle regulation. Ubiquitination by UHRF2 leads to its subsequent proteasomal degradation. Three alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3q12.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cell cycle |
| UniProt Code: | Q8WW12 |
| NCBI GenInfo Identifier: | 9966826 |
| NCBI Gene ID: | 57092 |
| NCBI Accession: | NP_065090.1 |
| UniProt Secondary Accession: | Q8WW12,Q53GF3, Q6AI44, Q96CU3, Q9NS81, B2RBE7, D3DN52 |
| UniProt Related Accession: | Q8WW12 |
| Molecular Weight: | 6,233 Da |
| NCBI Full Name: | Homo sapiens PEST proteolytic signal containing nuclear protein (PCNP), mRNA |
| NCBI Synonym Full Names: | PEST proteolytic signal containing nuclear protein |
| NCBI Official Symbol: | PCNP�� |
| NCBI Protein Information: | PEST proteolytic signal-containing nuclear protein; PEST-containing nuclear protein |
| UniProt Protein Name: | PEST proteolytic signal-containing nuclear protein |
| Protein Family: | PEST proteolytic signal-containing nuclear protein |
| UniProt Gene Name: | PCNP�� |
| UniProt Entry Name: | PCNP_HUMAN |
