Description
| Product Name: | Human OSGEP Recombinant Protein |
| Product Code: | RPPB5823 |
| Size: | 20µg |
| Species: | Human |
| Target: | OSGEP |
| Synonyms: | O-Sialoglycoprotein Endopeptidase, T(6)A37Threonylcarbamoyladenosine Biosynthesis Protein OSGEP, TRNAThreonylcarbamoyladenosine Biosynthesis Protein OSGEP, N6-L-ThreonylcarbamoyladenineSynthase, T(6)A Synthase, HOSGEP, GCPL1, Probable TRNAThreonylcarbamoyladenosine Biosynthesis Protein OSGEP, Probable TRNAN6-Adenosine Threonylcarbamoyltransferase , Probable O-SialoglycoproteinEndopeptidase, EC 3.4.24.57, EC 2.3.1.234, FLJ20411, OSGEP1, PRSMG1, KAE1, ProbabletRNA N6-adenosine threonylcarbamoyltransferase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | OSGEP protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPAVLGF EGSANKIGVG VVRDGKVLAN PRRTYVTPPG TGFLPGDTARHHRAVILDLL QEALTESGLT SQDIDCIAYT KGPGMGAPLV SVAVVARTVA QLWNKPLVGV NHCIGHIEMGRLITGATSPT VLYVSGGNTQ VIAYSEHRYR IFGETIDIAVGNCLDRFARV LKISNDPSPG YNIEQMAKRG KKLVELPYTV KGMDVSFSGILSFIEDVAHR MLATGECTPE DLCFSLQETV FAMLVEITER AMAHCGSQEA LIVGGVGCNV RLQEMMATMCQERGARLFAT DERFCIDNGA MIAQAGWEMF RAGHRTPLSD SGVTQRYRTD EVEVTWRD |
O-SialoglycoproteinEndopeptidase, also known as OSGEP is a member of the KAE1 / TsaD family.� OSGEP is essential for the formation ofthreonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs which readcodons beginning with adenine. OSGEP take a direct catalytic part in the abovereaction, however other proteins of the complex are required to fulfill thisactivity.
OSGEP Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 358 amino acids (1-335 a.a) andhaving a molecular mass of 38.8kDa.OSGEP is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OSGEP: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Belongs to the KAE1 / YgjD family. |
| UniProt Protein Details: | Protein type:Protease; EC 2.6.99.4 Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cytoplasm; nucleus Molecular Function:metal ion binding; transferase activity, transferring groups other than amino-acyl groups |
| UniProt Code: | Q9NPF4 |
| NCBI GenInfo Identifier: | 47605574 |
| NCBI Gene ID: | 55644 |
| NCBI Accession: | Q9NPF4.1 |
| UniProt Secondary Accession: | Q9NPF4,Q6IAC3, |
| UniProt Related Accession: | Q9NPF4 |
| Molecular Weight: | 335 |
| NCBI Full Name: | Probable tRNA N6-adenosine threonylcarbamoyltransferase |
| NCBI Synonym Full Names: | O-sialoglycoprotein endopeptidase |
| NCBI Official Symbol: | OSGEP�� |
| NCBI Official Synonym Symbols: | KAE1; GCPL1; OSGEP1; PRSMG1�� |
| NCBI Protein Information: | probable tRNA N6-adenosine threonylcarbamoyltransferase; OSGEP; hOSGEP; t(6)A synthase; N6-L-threonylcarbamoyladenine synthase; probable O-sialoglycoprotein endopeptidase; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP |
| UniProt Protein Name: | Probable tRNA N6-adenosine threonylcarbamoyltransferase |
| UniProt Synonym Protein Names: | N6-L-threonylcarbamoyladenine synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP |
| Protein Family: | Probable tRNA N6-adenosine threonylcarbamoyltransferase |
| UniProt Gene Name: | OSGEP�� |
| UniProt Entry Name: | OSGEP_HUMAN |
