Description
| Product Name: | Human OSCAR Recombinant Protein |
| Product Code: | RPPB4170 |
| Size: | 10µg |
| Species: | Human |
| Target: | OSCAR |
| Synonyms: | OSCAR, PIgR-3, PIGR3, hOSCAR, PIgR-3, Poly-Ig Receptor 3. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | OSCAR protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | DITPSVPPAS YHPKPWLGAQ PATVVTPGVN VTLRCRAPQP AWRFGLFKPG EIAPLLFRDV SSELAEFFLE EVTPAQGGSY RCCYRRPDWG PGVWSQPSDV LELLVTEELP RPSLVALPGP VVGPGANVSL RCAGRLRNMS FVLYREGVAA PLQYRHSAQP WADFTLLGAR APGTYSCYYH TPSAPYVLSQ RSEVLVISWE GEGPEARPAS SAPGMQAPGP PPSDPGAQAP SLSSFRPRGL VLQPLLPQTQ DSWDPAPPPS DPGVHHHHHH |
Osteoclast-associated immunoglobulin-like receptor isoform 6 or OSCAR, is a receptor for surfactant protein D that can be found on human myeloid cells. OSCAR is part of the TNF-? release from human CCR2+ inflammatory monocytes process. The protein is involved in antigen presentation and activation of dendritic cells. Preosteoclasts or mature osteoclasts express the OSCAR protein. Patients that suffer from RA (rheumatoid arthritis) has upregulations on monocytes which present increased proosteoclastogenic potential.
OSCAR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (19-282 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 270 amino acids and having a molecular mass of 29.2kDa.OSCAR shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: plasma membrane; integral to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q8IYS5 |
| NCBI GenInfo Identifier: | 311033418 |
| NCBI Gene ID: | 126014 |
| NCBI Accession: | Q8IYS5.3 |
| UniProt Secondary Accession: | Q8IYS5,Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2 B7WNS2 |
| UniProt Related Accession: | Q8IYS5 |
| Molecular Weight: | 30,481 Da |
| NCBI Full Name: | Osteoclast-associated immunoglobulin-like receptor |
| NCBI Synonym Full Names: | osteoclast associated, immunoglobulin-like receptor |
| NCBI Official Symbol: | OSCAR�� |
| NCBI Official Synonym Symbols: | PIGR3; PIgR-3�� |
| NCBI Protein Information: | osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2 |
| UniProt Protein Name: | Osteoclast-associated immunoglobulin-like receptor |
| UniProt Synonym Protein Names: | Polymeric immunoglobulin receptor 3 |
| Protein Family: | Protein |
| UniProt Gene Name: | OSCAR�� |
| UniProt Entry Name: | OSCAR_HUMAN |
