Description
| Product Name: | Human NUDC Recombinant Protein |
| Product Code: | RPPB4138 |
| Size: | 10µg |
| Species: | Human |
| Target: | NUDC |
| Synonyms: | Nuclear Distribution C Dynein Complex Regulator, NudC Nuclear Distribution Protein, Nuclear Distribution Protein C Homolog, Nuclear Distribution Gene C Homolog, Nuclear Distribution C Homolog, Nuclear Migration Protein NudC, NPD011, HNUDC, MNUDC, NUDC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NUDC protein solution (1mg/ml) containing 20mM Tris-HCl (pH 8.0), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGGEQEE ERFDGMLLAM AQQHEGGVQE LVNTFFSFLR RKTDFFIGGE EGMAEKLITQ TFSHHNQLAQ KTRREKRARQ EAERREKAER AARLAKEAKS ETSGPQIKEL TDEEAERLQL EIDQKKDAEN HEAQLKNGSL DSPGKQDTEE DEEEDEKDKG KLKPNLGNGA DLPNYRWTQT LSELDLAVPF CVNFRLKGKD MVVDIQRRHL RVGLKGQPAI IDGELYNEVK VEESSWLIED GKVVTVHLEK INKMEWWSRL VSSDPEINTK KINPENSKLS DLDSETRSMV EKMMYDQRQK SMGLPTSDEQ KKQEILKKFM DQHPEMDFSK AKFN |
Nuclear distribution gene C homolog (NUDC) is a nuclear distribution protein. The NUDC protein has a key role in mitosis and cytokinesis. NUDC is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. NUDC is required for correct formation of mitotic spindles and chromosome separation during mitosis, as well as cell proliferation. NUDC also has a role in neurogenesis and neuronal migration.
NUDC Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 354 amino acids (1-331 a.a) and having a molecular mass of 40.6kDa. NUDC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NUDC: a cytoskeletal protein that is a component of the dynactin complex. The cytoplasmic dynein/dynactin complex, a minus-end-directed motor, powers various) aspects of mitosis, including establishment of bipolarity, organization of spindle poles, alignment and segregation of chromosomes, as well as regulation of microtubule dynamics. Phosphorylation by PLK1 may play a critical role in cytokinesis. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:protein binding Biological Process: cell proliferation; multicellular organismal development; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9Y266 |
| NCBI GenInfo Identifier: | 62287138 |
| NCBI Gene ID: | 10726 |
| NCBI Accession: | Q9Y266.1 |
| UniProt Secondary Accession: | Q9Y266,Q5QP31, Q5QP35, Q9H0N2, Q9Y2B6, |
| UniProt Related Accession: | Q9Y266 |
| Molecular Weight: | 38,243 Da |
| NCBI Full Name: | Nuclear migration protein nudC |
| NCBI Synonym Full Names: | nuclear distribution C, dynein complex regulator |
| NCBI Official Symbol: | NUDC�� |
| NCBI Official Synonym Symbols: | HNUDC; MNUDC; NPD011�� |
| NCBI Protein Information: | nuclear migration protein nudC |
| UniProt Protein Name: | Nuclear migration protein nudC |
| UniProt Synonym Protein Names: | Nuclear distribution protein C homolog |
| Protein Family: | NADH pyrophosphatase |
| UniProt Gene Name: | NUDC�� |
| UniProt Entry Name: | NUDC_HUMAN |
