Description
| Product Name: | Human NRN1 Recombinant Protein |
| Product Code: | RPPB0795 |
| Size: | 10µg |
| Species: | Human |
| Target: | NRN1 |
| Synonyms: | Neuritin 1, NRN1, NRN, dJ380B8.2, Neuritin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | NRN1 was filtered (0.4 �m) and lyophilized in 20mM Tris buffer, 50mM NaCl, pH 8.0, 1% (w/v) Sucrose and 4% (w/v) Mannitol. |
| Solubility: | It is recommended to add 200�l of deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. NRN1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASAGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGNG |
Neuritin (NRN1) is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3 and other neural stimulators. NRN1 is expressed principally in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. NRN1 functions as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation.
Neuritin-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Ala28-Gly116) containing 99 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 11.02kDa.
| UniProt Protein Function: | NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6p25.1 Cellular Component: plasma membrane; synapse; cell junction Biological Process: nervous system development |
| NCBI Summary: | This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9NPD7 |
| NCBI GenInfo Identifier: | 74752881 |
| NCBI Gene ID: | 51299 |
| NCBI Accession: | Q9NPD7.1 |
| UniProt Secondary Accession: | Q9NPD7,Q7Z4Y1, B2RA93, |
| UniProt Related Accession: | Q9NPD7 |
| Molecular Weight: | 15,333 Da |
| NCBI Full Name: | Neuritin |
| NCBI Synonym Full Names: | neuritin 1 |
| NCBI Official Symbol: | NRN1�� |
| NCBI Official Synonym Symbols: | NRN; dJ380B8.2�� |
| NCBI Protein Information: | neuritin |
| UniProt Protein Name: | Neuritin |
| Protein Family: | Neuritin |
| UniProt Gene Name: | NRN1�� |
| UniProt Entry Name: | NRN1_HUMAN |
