Description
| Product Name: | Human NRGN Recombinant Protein |
| Product Code: | RPPB0793 |
| Size: | 10µg |
| Species: | Human |
| Target: | NRGN |
| Synonyms: | hng, RC3, Neurogranin, Ng, NRGN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NRGN protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH7.0), 30% glycerol 0.1mM PMSF and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDCCTEN ACSKPDDDIL DIPLDDPGAN AAAAKIQASF RGHMARKKIK SGERGRKGPG PGGPGGAGVA RGGAGGGPSG D |
Neurogranin (NRGN) is a calmodulin-binding protein which is expressed solely in the brain, mainly in dendritic spines. NRGN is also taking part in the protein kinase C signaling pathway by being a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. NRGN binds to calmodulin in the absence of calcium. NRGN protein�s phosphorylation by protein kinase C lowers its binding ability.
NRGN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-78 a.a.) and having a molecular mass of 10.0kDa (molecular size on SDS-PAGE will appear higher). NRGN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | neurogranin: Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Belongs to the neurogranin family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 11q24 Biological Process: nervous system development; signal transduction |
| NCBI Summary: | Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92686 |
| NCBI GenInfo Identifier: | 2498625 |
| NCBI Gene ID: | 4900 |
| NCBI Accession: | Q92686.1 |
| UniProt Related Accession: | Q92686 |
| Molecular Weight: | 7,618 Da |
| NCBI Full Name: | Neurogranin |
| NCBI Synonym Full Names: | neurogranin |
| NCBI Official Symbol: | NRGN�� |
| NCBI Official Synonym Symbols: | RC3; hng�� |
| NCBI Protein Information: | neurogranin |
| UniProt Protein Name: | Neurogranin |
| UniProt Synonym Protein Names: | RC3 |
| Protein Family: | Neurogranin |
| UniProt Gene Name: | NRGN�� |
| UniProt Entry Name: | NEUG_HUMAN |
