Description
| Product Name: | Human NRG4 Recombinant Protein |
| Product Code: | RPPB0792 |
| Size: | 10µg |
| Species: | Human |
| Target: | NRG4 |
| Synonyms: | Neuregulin 4, HRG4, Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG-4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | NRG4 protein solution (0.25mg/ml) contains 20mM Tris-HCl(pH8.0), 30% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL |
Neuregulin-4 (NRG4) is a part of the neuregulin family that owns 1 EGF-like domain and is a low affinity ligand for the ERBB4 tyrosine kinase receptor. NRG4 links ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
NRG4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 84 amino acids (1-61 a.a.) and having a molecular mass of 9.1kDa. NRG4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane Molecular Function:growth factor activity; receptor binding Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response |
| NCBI Summary: | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8WWG1 |
| NCBI GenInfo Identifier: | 28201832 |
| NCBI Gene ID: | 145957 |
| NCBI Accession: | Q8WWG1.1 |
| UniProt Secondary Accession: | Q8WWG1,A6NIE8, |
| UniProt Related Accession: | Q8WWG1 |
| Molecular Weight: | |
| NCBI Full Name: | Pro-neuregulin-4, membrane-bound isoform |
| NCBI Synonym Full Names: | neuregulin 4 |
| NCBI Official Symbol: | NRG4�� |
| NCBI Official Synonym Symbols: | HRG4�� |
| NCBI Protein Information: | pro-neuregulin-4, membrane-bound isoform; pro-NRG4; heregulin 4 |
| UniProt Protein Name: | Pro-neuregulin-4, membrane-bound isoform |
| Protein Family: | Pro-neuregulin |
| UniProt Gene Name: | NRG4�� |
| UniProt Entry Name: | NRG4_HUMAN |
