Description
| Product Name: | Human NMB Recombinant Protein |
| Product Code: | RPPB4104 |
| Size: | 10µg |
| Species: | Human |
| Target: | NMB |
| Synonyms: | Neuromedin-B, NMB, Neuromedin-B-32, Neuromedin B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NMB solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAPLSWDL PEPRSRASKI RVHSRGNLWA TGHFMGKKSL EPSSPSPLGT APHTSLRDQR LQLSHDLLGI LLLKKALGVS LSRPAPQIQY RRLLVQILQK |
Neuromedin B (NMB) which is a part of the bombesin/neuromedin-B/ranatensin family and stimulates smooth muscle contraction in a way similar to that of bombesin.
NMB Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (25-121) and having a molecular mass of 13.2 kDa.NMB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NMB: Stimulates smooth muscle contraction in a manner similar to that of bombesin. Belongs to the bombesin/neuromedin-B/ranatensin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q25.2 Cellular Component: extracellular region Molecular Function:hormone activity; protein binding Biological Process: cell-cell signaling; signal transduction |
| NCBI Summary: | This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P08949 |
| NCBI GenInfo Identifier: | 281185514 |
| NCBI Gene ID: | 4828 |
| NCBI Accession: | P08949.4 |
| UniProt Secondary Accession: | P08949,Q96A06, Q96HH5, |
| UniProt Related Accession: | P08949 |
| Molecular Weight: | 13kDa |
| NCBI Full Name: | Neuromedin-B |
| NCBI Synonym Full Names: | neuromedin B |
| NCBI Official Symbol: | NMB�� |
| NCBI Protein Information: | neuromedin-B |
| UniProt Protein Name: | Neuromedin-B |
| Protein Family: | Neuromedin |
| UniProt Gene Name: | NMB�� |
