Description
| Product Name: | Human NGB Recombinant Protein |
| Product Code: | RPPB0786 |
| Size: | 10µg |
| Species: | Human |
| Target: | NGB |
| Synonyms: | NGB. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered and lyophilized from 0.5mg/ml in 0.05M phosphate buffer, 0.1M NaCl, pH 7.2. |
| Solubility: | Add 0.2 ml of H2O and let the lyophilized pellet dissolve completely. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E |
Neuroglobin, 151 amino acid residue protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O (2) supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression.
17kDa protein containing 151 amino acid residues of the Neuroglobin human.
| UniProt Protein Function: | NGB: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Belongs to the globin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: mitochondrion; perikaryon Molecular Function:iron ion binding; heme binding; oxygen binding; oxygen transporter activity Biological Process: apoptosis; oxygen transport |
| NCBI Summary: | This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NPG2 |
| NCBI GenInfo Identifier: | 32171399 |
| NCBI Gene ID: | 58157 |
| NCBI Accession: | Q9NPG2.1 |
| UniProt Related Accession: | Q9NPG2 |
| Molecular Weight: | 151 |
| NCBI Full Name: | Neuroglobin |
| NCBI Synonym Full Names: | neuroglobin |
| NCBI Official Symbol: | NGB�� |
| NCBI Protein Information: | neuroglobin |
| UniProt Protein Name: | Neuroglobin |
| Protein Family: | Neuroglobin |
| UniProt Gene Name: | NGB�� |
| UniProt Entry Name: | NGB_HUMAN |
