Description
| Product Name: | Human NCR2 Recombinant Protein |
| Product Code: | RPPB4068 |
| Size: | 20µg |
| Species: | Human |
| Target: | NCR2 |
| Synonyms: | Natural Cytotoxicity Triggering Receptor 2, Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44), Natural Killer Cell P44-Related Protein, NK Cell-Activating Receptor, Lymphocyte Antigen 95 Homolog, CD336 Antigen, NK-p44, LY95, dJ149M18.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NCR2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSQAQSKAQV LQSVAGQTLT VRCQYPPTGS LYEKKGWCKE ASALVCIRLV TSSKPRTMAW TSRFTIWDDP DAGFFTVTMT DLREEDSGHY WCRIYRPSDN SVSKSVRFYL VVS |
NCR2 is a member of the natural cytotoxicity receptor (NCR) family and holds 1 immunoglobulin-like (Ig-like) domain. NCR2 cooperates with TYROBP/DAP12 and is specifically expressed by activated NK cells and by in vitro cultured TCRg/d lymphoid cells. NCR2 is a cytotoxicity-activating receptor which induces the amplified efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
NCR2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (19-130) and having a molecular mass of 15.0 kDa. NCR2 is fused to a 21 amino acid His-tag at N-terminus.
| UniProt Protein Function: | NCR2: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: innate immune response; cellular defense response; signal transduction |
| UniProt Code: | O95944 |
| NCBI GenInfo Identifier: | 251757303 |
| NCBI Gene ID: | 9436 |
| NCBI Accession: | O95944.2 |
| UniProt Secondary Accession: | O95944,Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2, |
| UniProt Related Accession: | O95944 |
| Molecular Weight: | 276 |
| NCBI Full Name: | Natural cytotoxicity triggering receptor 2 |
| NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 2 |
| NCBI Official Symbol: | NCR2�� |
| NCBI Official Synonym Symbols: | LY95; CD336; NKP44; NK-p44; dJ149M18.1�� |
| NCBI Protein Information: | natural cytotoxicity triggering receptor 2; NK cell-activating receptor; NK cell activating receptor (NKp44); natural killer cell p44-related protein; lymphocyte antigen 95 (activating NK-receptor; NK-p44); lymphocyte antigen 95 homolog (activating NK-rec |
| UniProt Protein Name: | Natural cytotoxicity triggering receptor 2 |
| UniProt Synonym Protein Names: | Lymphocyte antigen 95 homolog; NK cell-activating receptor; Natural killer cell p44-related protein; NK-p44; NKp44; CD_antigen: CD336 |
| Protein Family: | Natural cytotoxicity triggering receptor |
| UniProt Gene Name: | NCR2�� |
| UniProt Entry Name: | NCTR2_HUMAN |
