Description
| Product Name: | Human NAPSA Recombinant Protein |
| Product Code: | RPPB1998 |
| Size: | 10µg |
| Species: | Human |
| Target: | NAPSA |
| Synonyms: | Napsin A Aspartic Peptidase, NAP1, NAPA, Kidney-DerivedAspartic Protease-Like Protein, Aspartyl Protease 4, TA01/TA02, Napsin-1, SNAPA,Asp 4, ASP4, CTB-191K22.6, EC 3.4.23.15, Pronapsin A, EC 3.4.23.5, EC 3.4.23.3, EC3.4.23.-, EC 3.4.23, Napsin-A, KDAP, KAP,Napsin-A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NAPSA protein solution (0.25mg/ml) containing 20mMTris-HCl (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS NLWVPSRRCHFFSVPCWLHH RFDPKASSSF QANGTKFAIQ YGTGRVDGIL SEDKLTIGGI KGASVIFGEA LWEPSLVFAFAHFDGILGLG FPILSVEGVR PPMDVLVEQG LLDKPVFSFYLNRDPEEPDG GELVLGGSDP AHYIPPLTFV PVTVPAYWQI HMERVKVGPGLTLCAKGCAA ILDTGTSLIT GPTEEIRALH AAIGGIPLLA GEYIILCSEI PKLPAVSFLL GGVWFNLTAHDYVIQTTRNG VRLCLSGFQA LDVPPPAGPF WILGDVFLGT YVAVFDRGDM KSSARVGLARARTRGADLGW GETAQAQFPG |
Napsin A Aspartic Peptidase, also known as NAPSA is a member of thepeptidase A1 family. NAPSA is involved in the processing of pneumocytesurfactant precursors. Furthermore the activation peptides of aspartic proteinasestake part as inhibitors of the active site. These peptide segments/pro-parts areconsidered essential for correct folding, targeting, as well as control of theactivation of aspartic proteinase zymogens. The pronapsin A gene is expressed mostlyin lung and kidney. In addition, NAPSA translation product is expected to be afully functional, glycosylated aspartic proteinase precursor which contains anRGD motif as well as an additional 18 residues at its C-terminus.
NAPSA Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 380 amino acids (64-420 a.a) and having amolecular mass of 40.9kDa.NAPSA is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.23.-; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space; lysosome Molecular Function:aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; surfactant homeostasis |
| NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O96009 |
| NCBI GenInfo Identifier: | 6225749 |
| NCBI Gene ID: | 9476 |
| NCBI Accession: | O96009.1 |
| UniProt Secondary Accession: | O96009,Q8WWD9, |
| UniProt Related Accession: | O96009 |
| Molecular Weight: | 45,387 Da |
| NCBI Full Name: | Napsin-A |
| NCBI Synonym Full Names: | napsin A aspartic peptidase |
| NCBI Official Symbol: | NAPSA�� |
| NCBI Official Synonym Symbols: | KAP; Kdap; NAP1; NAPA; SNAPA�� |
| NCBI Protein Information: | napsin-A |
| UniProt Protein Name: | Napsin-A |
| UniProt Synonym Protein Names: | Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02 |
| Protein Family: | Napsin |
| UniProt Gene Name: | NAPSA�� |
