Description
| Product Name: | Human NABP1 Recombinant Protein |
| Product Code: | RPPB4049 |
| Size: | 20µg |
| Species: | Human |
| Target: | NABP1 |
| Synonyms: | Nucleic Acid Binding Protein 1, OBFC2A, Sensor OfSingle-Strand DNA Complex Subunit B2, Single-Stranded DNA-Binding Protein 2, SSB2,Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A, NucleicAcid-Binding Protein 1, Oligonucleotide/Oligosaccharide-Binding Fold-ContainingProtein 2A, Sensor Of SsDNA Subunit B2, SOSS-B2, SOSS Complex Subunit B2, hSSB2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | NABP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0) 0.2M, NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKVADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNPDYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR |
Nucleic acid binding protein 1 is a part of the SOSS complex, a multiprotein complexwhich functions downstream of the MRN complex to promote DNA repair and G2/Mcheckpoint. In the SOSS complex,NABP1 acts as a sensor of single-stranded DNA which binds to single-strandedDNA, in particularto polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpointactivation, recombinational repair and maintenance of genomic stability. NABP1 is essential forefficient homologous recombination-dependent repair of double-strand breaks (DSBs) andATM-dependent signaling pathways.
NABP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) and having a molecular mass of 24.8kDa.NABP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; DNA repair, damage; Cell cycle regulationChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleusMolecular Function: protein binding; RNA binding; single-stranded DNA bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation |
| UniProt Protein Details: | |
| NCBI Summary: | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] |
| UniProt Code: | Q96AH0 |
| NCBI GenInfo Identifier: | 72534722 |
| NCBI Gene ID: | 64859 |
| NCBI Accession: | NP_001026886.1 |
| UniProt Secondary Accession: | Q96AH0,Q658Y8, Q9H5X6 |
| UniProt Related Accession: | Q96AH0 |
| Molecular Weight: | 14,677 Da |
| NCBI Full Name: | SOSS complex subunit B2 isoform 1 |
| NCBI Synonym Full Names: | nucleic acid binding protein 1 |
| NCBI Official Symbol: | NABP1�� |
| NCBI Official Synonym Symbols: | SSB2; OBFC2A; SOSS-B2�� |
| NCBI Protein Information: | SOSS complex subunit B2 |
| UniProt Protein Name: | SOSS complex subunit B2 |
| UniProt Synonym Protein Names: | Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2 |
| Protein Family: | SOSS complex |
| UniProt Gene Name: | NABP1�� |
| UniProt Entry Name: | SOSB2_HUMAN |
