Description
| Product Name: | Human MORF4L2 Recombinant Protein |
| Product Code: | RPPB3991 |
| Size: | 20µg |
| Species: | Human |
| Target: | MORF4L2 |
| Synonyms: | Mortality factor 4-like protein 2, MORF-related gene X protein, Protein MSL3-2, Transcription factor-like protein MRGX, MORF4L2, KIAA0026, MRGX, MORFL2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MORF4L2 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL |
MORF4L2 belongs to the mortality factor (MORF) family of transcriptional regulator which is involved in cell growth, regulation and senescence. MORF4L2 localizes to the nucleus, and it has a protein kinase C phosphorylation site as well as a tyrosine phosphorylation site. MORF4L2 interacts with the Rb tumor suppressor through its helix-loop-helix and leucine zipper regions. Furthermore, MORF4L2 has histone deacetylase activity and can either repress or promote the activity of the B-Myb promoter depending on the tissue.
MORF4L2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-288 a.a.) and having a molecular mass of 34.4kDa (Molecular weight on SDS-PAGE will appear higher).MORF4L2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MORF4L2: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: Xq22 Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding Biological Process: chromatin remodeling; chromatin silencing; histone deacetylation |
| UniProt Code: | Q15014 |
| NCBI GenInfo Identifier: | 3123049 |
| NCBI Gene ID: | 9643 |
| NCBI Accession: | Q15014.1 |
| UniProt Secondary Accession: | Q15014,Q567V0, Q8J026, B3KP92, D3DXA5, |
| UniProt Related Accession: | Q15014 |
| Molecular Weight: | 32,308 Da |
| NCBI Full Name: | Mortality factor 4-like protein 2 |
| NCBI Synonym Full Names: | mortality factor 4 like 2 |
| NCBI Official Symbol: | MORF4L2�� |
| NCBI Official Synonym Symbols: | MRGX; MORFL2�� |
| NCBI Protein Information: | mortality factor 4-like protein 2 |
| UniProt Protein Name: | Mortality factor 4-like protein 2 |
| UniProt Synonym Protein Names: | MORF-related gene X protein; Protein MSL3-2; Transcription factor-like protein MRGX |
| Protein Family: | Mortality factor 4-like protein |
| UniProt Gene Name: | MORF4L2�� |
| UniProt Entry Name: | MO4L2_HUMAN |
