Description
| Product Name: | Human M6PR Recombinant Protein |
| Product Code: | RPPB3900 |
| Size: | 10µg |
| Species: | Human |
| Target: | M6PR |
| Synonyms: | Mannose-6-Phosphate Receptor (Cation Dependent), CD-MPR, MPR46, CD Man-6-P Receptor, MPR 46, 46-KDa Mannose 6-Phosphate Receptor, MPR-46, SMPR, Cation-Dependent Mannose-6-Phosphate Receptor, Mr 46,000 Man6PR, Small Mannose 6-Phosphate Receptor, 46 KDa Mannose 6-Phosphate Receptor, MPRD, M6PR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The M6PR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH |
Mannose-6-Phosphate Receptor (M6PR) belongs to the P-type lectin family. P-type lectins play a vital role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The M6PR protein functions as a homodimer and needs divalent cations for ligand binding. Lysosomal enzymes carrying phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ensuing receptor-ligand complex is transferred to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
M6PR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (27-185) and having a molecular mass of 20.3kDa.M6PR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: endosome; integral to plasma membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle Molecular Function:transmembrane receptor activity Biological Process: endosome to lysosome transport; receptor-mediated endocytosis |
| NCBI Summary: | This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011] |
| UniProt Code: | P20645 |
| NCBI GenInfo Identifier: | 127293 |
| NCBI Gene ID: | 4074 |
| NCBI Accession: | P20645.1 |
| UniProt Secondary Accession: | P20645,A8K528, D3DUV5, |
| UniProt Related Accession: | P20645 |
| Molecular Weight: | 30,993 Da |
| NCBI Full Name: | Cation-dependent mannose-6-phosphate receptor |
| NCBI Synonym Full Names: | mannose-6-phosphate receptor, cation dependent |
| NCBI Official Symbol: | M6PR�� |
| NCBI Official Synonym Symbols: | SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR�� |
| NCBI Protein Information: | cation-dependent mannose-6-phosphate receptor |
| UniProt Protein Name: | Cation-dependent mannose-6-phosphate receptor |
| UniProt Synonym Protein Names: | 46 kDa mannose 6-phosphate receptor; MPR 46 |
| Protein Family: | Cation-dependent mannose-6-phosphate receptor |
| UniProt Gene Name: | M6PR�� |
| UniProt Entry Name: | MPRD_HUMAN |
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