Description
| Product Name: | Human LY9 Recombinant Protein |
| Product Code: | RPPB3894 |
| Size: | 5µg |
| Species: | Human |
| Target: | LY9 |
| Synonyms: | Lymphocyte Antigen 9, Signaling Lymphocytic Activation Molecule 3, Cell Surface Molecule Ly-9, SLAM Family Member 3, SLAMF3, CD229 Antigen, CD229, Hly9, MLY9, LY9. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LY9 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLKDSAPTV VSGILGGSVT LPLNISVDTE IENVIWIGPK NALAFARPKE NVTIMVKSYL GRLDITKWSY SLCISNLTLN DAGSYKAQIN QRNFEVTTEE EFTLFVYEQL QEPQVTMKSV KVSENFSCNI TLMCSVKGAE KSVLYSWTPR EPHASESNGG SILTVSRTPC DPDLPYICTA QNPVSQRSSL PVHVGQFCTD PGASRGGTTG ETVVGVLGEP VTLPLALPAC RDTEKVVWLF NTSIISKERE EAATADPLIK SRDPYKNRVW VSSQDCSLKI SQLKIEDAGP YHAYVCSEAS SVTSMTHVTL LIYRRLRKPK ITWSLRHSED GICRISLTCS VEDGGNTVMY TWTPLQKEAV VSQGESHLNV SWRSSENHPN LTCTASNPVS RSSHQFLSEN ICSGPERNTK HHHHHH |
Lymphocyte Antigen 9, also known as LY9 is a member of the SLAM familyof immunomodulatory receptors, LY9 interacts with the adaptor molecule SAP . LY9 plays a part in adhesion reactions between T lymphocytes andaccessory cells via homophilic interaction. LY9 promotes T-cell differentiationinto a helper T-cell Th17 phenotype which leads to increased IL-17 secretion;the costimulatory activity requires SH2D1A. Furthermore it also promotesrecruitment of RORC to the IL-17 promoter. LY9 is implicated in the maintenanceof peripheral cell tolerance through serving as a negative regulator of theimmune response. LY9 disables autoantibody responses as well as inhibitsIFN-gamma secretion by CD4(+) T-cells. Moreover, LY9 negatively regulate thesize of thymic innate CD8(+) T-cells and the development of invariant naturalkiller T (iNKT) cells. Systemic Lupus Erythematosus is one of the diseases whichare associated with LY9.�
LY9 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 416 amino acids (48-454 aa) and having a molecular mass of 45.9kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).LY9 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD229: May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: integral to membrane Molecular Function:receptor activity Biological Process: cell adhesion |
| NCBI Summary: | LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9HBG7 |
| NCBI GenInfo Identifier: | 75991709 |
| NCBI Gene ID: | 4063 |
| NCBI Accession: | NP_001028839.1 |
| UniProt Secondary Accession: | Q9HBG7,Q14775, Q5VYI3, Q6P2J4, Q9H4N5, Q9NQ24, A8K7N3 |
| UniProt Related Accession: | Q9HBG7 |
| Molecular Weight: | |
| NCBI Full Name: | T-lymphocyte surface antigen Ly-9 isoform b |
| NCBI Synonym Full Names: | lymphocyte antigen 9 |
| NCBI Official Symbol: | LY9�� |
| NCBI Official Synonym Symbols: | hly9; mLY9; CD229; SLAMF3�� |
| NCBI Protein Information: | T-lymphocyte surface antigen Ly-9 |
| UniProt Protein Name: | T-lymphocyte surface antigen Ly-9 |
| UniProt Synonym Protein Names: | Cell surface molecule Ly-9; Lymphocyte antigen 9; SLAM family member 3; SLAMF3; Signaling lymphocytic activation molecule 3; CD_antigen: CD229 |
| Protein Family: | T-lymphocyte surface antigen |
| UniProt Gene Name: | LY9�� |
| UniProt Entry Name: | LY9_HUMAN |
