Description
| Product Name: | Human LRRC59 Recombinant Protein |
| Product Code: | RPPB3878 |
| Size: | 10µg |
| Species: | Human |
| Target: | LRRC59 |
| Synonyms: | Leucine Rich Repeat Containing 59, Ribosome-Binding Protein P34, p34, Leucine-Rich Repeat-Containing Protein 59. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The LRRC59 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT, 2mM EDTA and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTKAGSK GGNLRDKLDG NELDLSLSDL NEVPVKELAA LPKATILDLS CNKLTTLPSD FCGLTHLVKL DLSKNKLQQL PADFGRLVNL QHLDLLNNKL VTLPVSFAQL KNLKWLDLKD NPLDPVLAKV AGDCLDEKQC KQCANKVLQH MKAVQADQER ERQRRLEVER EAEKKREAKQ RAKEAQEREL RKREKAEEKE RRRKEYDALK AAKREQEKKP KKEANQAPKS KSGSRPRKPP PRKHTRS |
LRRC59 controls nuclear import of exogenous FGF1 by enabling interaction with the nuclear import mechanism and by transporting cytosolic FGF1 to and through the nuclear pores. LRRC59 is essential for nuclear import of FGF1, but not that of FGF2.
LRRC59 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 267 amino acids (1-244) and having a molecular mass of 30.3kDa.LRRC59 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LRRC59: Interacts with SGOL1. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17q21.33 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; nuclear envelope |
| UniProt Code: | Q96AG4 |
| NCBI GenInfo Identifier: | 40254924 |
| NCBI Gene ID: | 55379 |
| NCBI Accession: | NP_060979.2 |
| UniProt Secondary Accession: | Q96AG4,Q9P189, B2RE83, D3DTX8, |
| UniProt Related Accession: | Q96AG4 |
| Molecular Weight: | Calculated MW: 35kDaMolecular Weight: 307 |
| NCBI Full Name: | leucine-rich repeat-containing protein 59 |
| NCBI Synonym Full Names: | leucine rich repeat containing 59 |
| NCBI Official Symbol: | LRRC59�� |
| NCBI Official Synonym Symbols: | p34; PRO1855�� |
| NCBI Protein Information: | leucine-rich repeat-containing protein 59 |
| UniProt Protein Name: | Leucine-rich repeat-containing protein 59 |
| UniProt Synonym Protein Names: | Ribosome-binding protein p34; p34 |
| Protein Family: | Leucine-rich repeat-containing protein |
| UniProt Gene Name: | LRRC59�� |
| UniProt Entry Name: | LRC59_HUMAN |
![[KO Validated] LRRC59 Rabbit Polyclonal Antibody (CAB19965)](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/150762/150543/anti-lrrc59-antibody-cab19965ko-validated__56512__62045.1750436212.jpg?c=1 "[KO Validated] LRRC59 Rabbit Polyclonal Antibody (CAB19965)")
