Description
| Product Name: | Human LGALS9 Recombinant Protein |
| Product Code: | RPPB0290 |
| Size: | 10µg |
| Species: | Human |
| Target: | LGALS9 |
| Synonyms: | Lectin galactoside-binding soluble 9, Urate transporter/channel protein, LGALS9A, MGC125973, HUAT, Ecalectin, Galectin-9, MGC117375, MGC125974, HOM-HD-21, LGALS9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The LGALS9 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQ |
LGLAS9 binds galactosides and has high affinity for the Forssman pentasaccharide. LGLAS9 participates in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. LGLAS9 is a ligand for HAVCR2/TIM3. LGLAS9 Induces T-helper type 1 lymphocyte (Th1) death. LGLAS9 performs as an eosinophil chemoattractant LGLAS9 is an S-type lectin which is over-expressed in Hodgkin's disease tissue and takes part in the interaction between the H&RS cells with their surrounding cells.
LGALS9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (1-148 a.a.) and having a molecular mass of 18.5 kDa. Galectin-9 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | galectin-9: Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: cytoplasm; extracellular space; intracellular; nucleus Molecular Function:carbohydrate binding; disaccharide binding; enzyme binding; galactose binding; signal transducer activity Biological Process: activation of NF-kappaB transcription factor; female pregnancy; inflammatory response; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of activated T cell proliferation; negative regulation of chemokine production; negative regulation of interferon-gamma production; negative regulation of mast cell degranulation; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-4 production; positive regulation of NF-kappaB import into nucleus; positive regulation of virion penetration into host cell; regulation of interleukin-4 production; regulation of interleukin-5 production; response to lipopolysaccharide; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway |
| NCBI Summary: | The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00182 |
| NCBI GenInfo Identifier: | 3041694 |
| NCBI Gene ID: | 3965 |
| NCBI Accession: | O00182.2 |
| UniProt Secondary Accession: | O00182,O14532, O75028, Q3B8N1, Q53FQ0, Q8WYQ7, Q9NQ58 A7VJG6, F8W9W4, |
| UniProt Related Accession: | O00182 |
| Molecular Weight: | 38,321 Da |
| NCBI Full Name: | Galectin-9 |
| NCBI Synonym Full Names: | galectin 9 |
| NCBI Official Symbol: | LGALS9�� |
| NCBI Official Synonym Symbols: | HUAT; LGALS9A�� |
| NCBI Protein Information: | galectin-9 |
| UniProt Protein Name: | Galectin-9 |
| UniProt Synonym Protein Names: | Ecalectin; Tumor antigen HOM-HD-21 |
| Protein Family: | Galectin |
| UniProt Gene Name: | LGALS9�� |
| UniProt Entry Name: | LEG9_HUMAN |
