Description
| Product Name: | Human LAMP1 Recombinant Protein |
| Product Code: | RPPB3837 |
| Size: | 10µg |
| Species: | Human |
| Target: | LAMP1 |
| Synonyms: | Lysosome-associated membrane glycoprotein 1, LAMP1, CD107a, LAMPA, LGP120, LAMP-1, CD107 antigen-like family member A. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LAMP1 protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPAMFMVKN GNGTACIMAN FSAAFSVNYD TKSGPKNMTF DLPSDATVVL NRSSCGKENT SDPSLVIAFG RGHTLTLNFT RNATRYSVQL MSFVYNLSDT HLFPNASSKE IKTVESITDI RADIDKKYRC VSGTQVHMNN VTVTLHDATI QAYLSNSSFS RGETRCEQDR PSPTTAPPAPPSPSPSPVPK SPSVDKYNVS GTNGTCLLAS MGLQLNLTYE RKDNTTVTRL LNINPNKTSA SGSCGAHLVT LELHSEGTTV LLFQFGMNAS SSRFFLQGIQ LNTILPDARD PAFKAANGSL RALQATVGNS YKCNAEEHVR VTKAFSVNIF KVWVQAFKVE GGQFGSVEEC LLDENSMHHHHHH |
Lysosomal-Associated Membrane Protein 1 (LAMP1) is a part of the LAMP family. �LAMP1 is a membrane protein which is expressed in the endosome-lysosome membranes of cells and is implicated in tumor cell metastasis. A glycoform of LAMP1 is expressed on the surface of activated macrophages and promotes T cell costimulation and a Th1 biased immune response. �LAMP1 is also found on the plasma membrane during the activation of NK cells, CD8 & T cells, monocytes, basophils, and platelets.
LAMP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 363 amino acids (29-382a.a.) and having a molecular mass of 39.4kDa. (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).LAMP1 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q34 Cellular Component: integral to plasma membrane; lysosome; dendrite; multivesicular body; cell soma; membrane; late endosome; cytoplasm; plasma membrane; melanosome; endosome membrane; sarcolemma; external side of plasma membrane Molecular Function:protein domain specific binding; protein binding; enzyme binding Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; viral reproduction; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity |
| NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11279 |
| NCBI GenInfo Identifier: | 206729915 |
| NCBI Gene ID: | 3916 |
| NCBI Accession: | P11279.3 |
| UniProt Secondary Accession: | P11279,Q8WU33, Q96I40, Q9BRD2, Q9NP13, B4DWL3, |
| UniProt Related Accession: | P11279 |
| Molecular Weight: | 417 |
| NCBI Full Name: | Lysosome-associated membrane glycoprotein 1 |
| NCBI Synonym Full Names: | lysosomal-associated membrane protein 1 |
| NCBI Official Symbol: | LAMP1�� |
| NCBI Official Synonym Symbols: | LAMPA; CD107a; LGP120�� |
| NCBI Protein Information: | lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1 |
| UniProt Protein Name: | Lysosome-associated membrane glycoprotein 1 |
| UniProt Synonym Protein Names: | CD107 antigen-like family member A; CD_antigen: CD107a |
| Protein Family: | Lysosome-associated membrane glycoprotein |
| UniProt Gene Name: | LAMP1�� |
| UniProt Entry Name: | LAMP1_HUMAN |
