Description
| Product Name: | Human KCTD15 Recombinant Protein |
| Product Code: | RPPB3780 |
| Size: | 20µg |
| Species: | Human |
| Target: | KCTD15 |
| Synonyms: | BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerisation domain containing 15, KCTD15, MGC2628, MGC25497. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KCTD15 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI DVGSHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QDVL |
KCTD15 protein is encoded in humans by the KCTD15 gene. KCTD15 is expressed at a high level in the brain and the hypothalamus. The potassium channel KCTD15 was identified as a genetic loci linked to higher than normal BMI in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. SNPs (Single nucleotide polymorphisms) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still notably associated with higher than normal BMI levels.
KCTD15 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 254 amino acids (1-234 a.a) and having a molecular mass of 28.6kDa.KCTD15 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KCTD15: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.11 Biological Process: multicellular organismal development; protein homooligomerization |
| UniProt Code: | Q96SI1 |
| NCBI GenInfo Identifier: | 74732704 |
| NCBI Gene ID: | 79047 |
| NCBI Accession: | Q96SI1.1 |
| UniProt Secondary Accession: | Q96SI1,Q9BVI6, A8K600, |
| UniProt Related Accession: | Q96SI1 |
| Molecular Weight: | 26,476 Da |
| NCBI Full Name: | BTB/POZ domain-containing protein KCTD15 |
| NCBI Synonym Full Names: | potassium channel tetramerization domain containing 15 |
| NCBI Official Symbol: | KCTD15�� |
| NCBI Protein Information: | BTB/POZ domain-containing protein KCTD15; potassium channel tetramerisation domain containing 15; potassium channel tetramerization domain-containing protein 15 |
| UniProt Protein Name: | BTB/POZ domain-containing protein KCTD15 |
| UniProt Synonym Protein Names: | Potassium channel tetramerization domain-containing protein 15 |
| Protein Family: | BTB/POZ domain-containing protein |
| UniProt Gene Name: | KCTD15�� |
| UniProt Entry Name: | KCD15_HUMAN |
