Description
| Product Name: | Human JTB Recombinant Protein |
| Product Code: | RPPB3773 |
| Size: | 10µg |
| Species: | Human |
| Target: | JTB |
| Synonyms: | Protein JTB, Jumping translocation breakpoint protein, Prostate androgen-regulated protein, PAR protein, Jumping Translocation Breakpoint, JTB, Jumping translocation breakpoint, hJT, HJTB, HSPC222, PAR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | JTB protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEAPVQEE KLSASTSNLP CWLVEEFVVA EECSPCSNFR AKTTPECGPT GYVEKITCSS SKRNEFKSCR SALMEQRL |
Jumping Translocation Breakpoint (JTB) takes part in the regulation of cell proliferation and is essential for cytokinesis during mitosis. JTB inhibits apoptosis induced by TGFB1 and increases AURKB activity. JTB is also a part of the chromosomal passenger complex (CPC) which is a key regulator of mitosis.
JTB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (31-105 a.a.) and having a molecular mass of 10.7kDa.JTB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | JTB: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Belongs to the JTB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: centrosome; cytoplasm; integral to plasma membrane; membrane; midbody; spindle Molecular Function:protein kinase binding Biological Process: cytokinesis; mitotic cell cycle; positive regulation of protein kinase activity |
| UniProt Code: | O76095 |
| NCBI GenInfo Identifier: | 6016408 |
| NCBI Gene ID: | 10899 |
| NCBI Accession: | O76095.1 |
| UniProt Secondary Accession: | O76095,O95442, Q6IB19, Q9P0Q4, |
| UniProt Related Accession: | O76095 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Protein JTB |
| NCBI Synonym Full Names: | jumping translocation breakpoint |
| NCBI Official Symbol: | JTB�� |
| NCBI Official Synonym Symbols: | PAR; hJT; HJTB; HSPC222�� |
| NCBI Protein Information: | protein JTB |
| UniProt Protein Name: | Protein JTB |
| UniProt Synonym Protein Names: | Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein |
| Protein Family: | Protein |
| UniProt Gene Name: | JTB�� |
