Description
| Product Name: | Human JAM3 Recombinant Protein |
| Product Code: | RPPB3766 |
| Size: | 10µg |
| Species: | Human |
| Target: | JAM3 |
| Synonyms: | Junctional Adhesion Molecule 3, Junctional Adhesion Molecule C, JAM-C, JAM-2, JAM-3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The JAM3 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM EDTA, 5mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVNLKSS NRTPVVQEFE SVELSCIITD SQTSDPRIEW KKIQDEQTTY VFFDNKIQGD LAGRAEILGK TSLKIWNVTR RDSALYRCEV VARNDRKEID EIVIELTVQV KPVTPVCRVP KAVPVGKMAT LHCQESEGHP RPHYSWYRND VPLPTDSRAN PRFRNSSFHL NSETGTLVFT AVHKDDSGQY YCIASNDAGS ARCEEQEMEV YDLN |
JAM3 belongs to the junctional adhesion molecule protein family and functions as a receptor for another member of this family. JAM3 plays a part in cell-cell adhesion. The soluble form of JAM3 is a mediator of angiogenesis. JAM3 is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). A mutation in an intron of the JAM3 gene is linked with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.
JAM3 Human Recombinant produced in E. coli is a single polypeptide chain containing 234 amino acids (32-241) and having a molecular mass of 26.0 kDa.JAM3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | JAM3: Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. Defects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC). A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q25 Cellular Component: desmosome; extracellular space; Golgi apparatus; plasma membrane Molecular Function:integrin binding; protein binding Biological Process: angiogenesis; extracellular matrix organization and biogenesis; leukocyte migration Disease: Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts |
| NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] |
| UniProt Code: | Q9BX67 |
| NCBI GenInfo Identifier: | 51701611 |
| NCBI Gene ID: | 83700 |
| NCBI Accession: | Q9BX67.1 |
| UniProt Secondary Accession: | Q9BX67,Q8WWL8, Q96FL1, B3KWG9, |
| UniProt Related Accession: | Q9BX67 |
| Molecular Weight: | 29,223 Da |
| NCBI Full Name: | Junctional adhesion molecule C |
| NCBI Synonym Full Names: | junctional adhesion molecule 3 |
| NCBI Official Symbol: | JAM3�� |
| NCBI Official Synonym Symbols: | JAMC; JAM-2; JAM-3; JAM-C�� |
| NCBI Protein Information: | junctional adhesion molecule C |
| UniProt Protein Name: | Junctional adhesion molecule C |
| UniProt Synonym Protein Names: | JAM-2; Junctional adhesion molecule 3; JAM-3 |
| Protein Family: | Junctional adhesion molecule |
| UniProt Gene Name: | JAM3�� |
| UniProt Entry Name: | JAM3_HUMAN |
