Description
| Product Name: | Human IMPA2 Recombinant Protein |
| Product Code: | RPPB1849 |
| Size: | 10µg |
| Species: | Human |
| Target: | IMPA2 |
| Synonyms: | Inositol monophosphatase 2, IMP 2, IMPase 2, Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2, IMPA2, IMP.18P. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IMPA2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK |
IMPA2 is a member of the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate and has a significant role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li(+) action in brain. IMPA2 is considered to have a role in schizophrenia and bipolar disorder.
IMPA2 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�308 amino acids (1-288 a.a.) and having a molecular mass of 33.5kDa. The IMPA2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IMPA2: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; Motility/polarity/chemotaxis; Phosphatase (non-protein) Chromosomal Location of Human Ortholog: 18p11.21 Cellular Component: cytoplasm; cytosol Molecular Function:inositol-1(or 4)-monophosphatase activity; protein binding; protein homodimerization activity Biological Process: inositol metabolic process; inositol phosphate dephosphorylation; inositol phosphate metabolic process; phosphate metabolic process; signal transduction |
| NCBI Summary: | This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011] |
| UniProt Code: | O14732 |
| NCBI GenInfo Identifier: | 3914095 |
| NCBI Gene ID: | 3613 |
| NCBI Accession: | O14732.1 |
| UniProt Secondary Accession: | O14732,Q9UJT3, B0YJ29, |
| UniProt Related Accession: | O14732 |
| Molecular Weight: | 31kDa |
| NCBI Full Name: | Inositol monophosphatase 2 |
| NCBI Synonym Full Names: | inositol monophosphatase 2 |
| NCBI Official Symbol: | IMPA2�� |
| NCBI Protein Information: | inositol monophosphatase 2 |
| UniProt Protein Name: | Inositol monophosphatase 2 |
| UniProt Synonym Protein Names: | Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2 |
| UniProt Gene Name: | IMPA2�� |
