Description
| Product Name: | Human IL18R1 Recombinant Protein |
| Product Code: | RPPB0627 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL18R1 |
| Synonyms: | Interleukin 18 Receptor 1, CD218 Antigen-Like Family Member A, IL1 Receptor-Related Protein, IL-18R-1, CDw218a, IL-18R1, IL-1Rrp, IL1R-Rp, IL1RRP, Interleukin-18 Receptor 1, Cytokine Receptor, CD218a Antigen, IL18Ralpha2, CD218a, IL18RA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL18R1 protein solution (0.5mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AESCTSRPHI TVVEGEPFYL KHCSCSLAHE IETTTKSWYK SSGSQEHVEL NPRSSSRIAL HDCVLEFWPV ELNDTGSYFF QMKNYTQKWK LNVIRRNKHS CFTERQVTSK IVEVKKFFQI TCENSYYQTL VNSTSLYKNC KKLLLENNKN PTIKKNAEFE DQGYYSCVHF LHHNGKLFNI TKTFNITIVE DRSNIVPVLL GPKLNHVAVE LGKNVRLNCS ALLNEEDVIY WMFGEENGSD PNIHEEKEMR IMTPEGKWHA SKVLRIENIG ESNLNVLYNC TVASTGGTDT KSFILVRKAD MADIPGHVFT RVEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSLSPGKHHHHHH |
IL18R1 (interleukin 18 receptor 1) is an interleukin receptor which is part of the immunoglobulin superfamily. IL18R1 comprises 3 Ig-like C2-type domains, on TIR domain IL18R1 shares many immuno-regulatory functions with IL12. IL12 and IFN-alpha are found to induce the expression of IL18 receptor in NK & T cells. Moreover, IL18R1 explicitly binds interleukin 18, and is vital for IL18 mediated signal transduction. IL18R1 does not bind IL1A or IL1B beta, however it does bind to the agonist which causes NF-kappa-B to become active.
IL18R1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing a total of 550 amino acids (19-329 a.a.) and having a molecular mass of 62.7kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). IL18R1 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL18R1: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q12 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding; receptor activity; interleukin-1 receptor activity; interleukin-18 receptor activity Biological Process: positive regulation of interferon-gamma production; T-helper 1 cell differentiation; natural killer cell activation; immune response; positive regulation of NF-kappaB import into nucleus; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q13478 |
| NCBI GenInfo Identifier: | 26395370 |
| NCBI Gene ID: | 8809 |
| NCBI Accession: | Q13478.1 |
| UniProt Secondary Accession: | Q13478,Q52LC9, B2R9Y5, |
| UniProt Related Accession: | Q13478 |
| Molecular Weight: | 62,304 Da |
| NCBI Full Name: | Interleukin-18 receptor 1 |
| NCBI Synonym Full Names: | interleukin 18 receptor 1 |
| NCBI Official Symbol: | IL18R1�� |
| NCBI Official Synonym Symbols: | CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp�� |
| NCBI Protein Information: | interleukin-18 receptor 1; IL-18R1; IL1R-rp; IL-18R-1; IL18Ralpha2; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A |
| UniProt Protein Name: | Interleukin-18 receptor 1 |
| UniProt Synonym Protein Names: | CD218 antigen-like family member A; CDw218a; IL1 receptor-related protein; IL-1Rrp; IL1R-rp; CD_antigen: CD218a |
| Protein Family: | Interleukin-18 receptor |
| UniProt Gene Name: | IL18R1�� |
| UniProt Entry Name: | IL18R_HUMAN |
