Description
| Product Name: | Human IL18BP Recombinant Protein |
| Product Code: | RPPB0622 |
| Size: | 20µg |
| Species: | Human |
| Target: | IL18BP |
| Synonyms: | Interleukin 18 Binding Protein, MC51L-53L-54L HomologGene Product, Tadekinig-Alfa, IL-18BP, IL18BPa, Interleukin-18-binding protein, Tadekinig-alfa. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | IL18BP protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVPLNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTNFSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSHSSPQQQG |
Interleukin-18 Binding Protein (IL18BP) serves as an inhibitor of the proinflammatory cytokine, IL18. IL18BP binds IL18, inhibits the binding of IL18 to its receptor, and consequently inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. The IL18BP protein is constitutively expressed and secreted in mononuclear cells. Elevated levels of IL18BP protein are detected in the intestinal tissues of patients with Crohn's disease.
IL18BP Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 187 amino acids (31-194 a.a) andhaving a molecular mass of 20kDa.IL18BP is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; extracellular region Molecular Function:receptor antagonist activity; interleukin-18 binding Biological Process: T-helper 1 type immune response; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | O95998 |
| NCBI GenInfo Identifier: | 251757286 |
| NCBI Gene ID: | 10068 |
| NCBI Accession: | O95998.2 |
| UniProt Secondary Accession: | O95998,O95993, O96027, Q9NZA9, Q9UBR7, B3KUZ0, B7WPK4 |
| UniProt Related Accession: | O95998 |
| Molecular Weight: | 17,478 Da |
| NCBI Full Name: | Interleukin-18-binding protein |
| NCBI Synonym Full Names: | interleukin 18 binding protein |
| NCBI Official Symbol: | IL18BP�� |
| NCBI Official Synonym Symbols: | IL18BPa�� |
| NCBI Protein Information: | interleukin-18-binding protein; IL-18BP; MC51L-53L-54L homolog gene product; tadekinig-alfa |
| UniProt Protein Name: | Interleukin-18-binding protein |
| UniProt Synonym Protein Names: | Tadekinig-alfa |
| Protein Family: | Interleukin-18-binding protein |
| UniProt Gene Name: | IL18BP�� |
| UniProt Entry Name: | I18BP_HUMAN |
