Description
| Product Name: | Human IL17RB Recombinant Protein |
| Product Code: | RPPB0618 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL17RB |
| Synonyms: | Interleukin17 Receptor B, IL17RH1, IL17BR, Interleukin 17B Receptor, Cytokine,Receptor-Like 4, Interleukin-17B Receptor, IL-17 Receptor Homolog 1, IL-17Receptor B, IL-17B Receptor, IL-17Rh1, IL-17RB, EVI27, CRL4, Interleukin 17Receptor Homolog 1, Interleukin-17 Receptor B, Cytokine Receptor CRL4. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | IL17RB protein solution (0.25mg/ml) containing phosphatebuffered saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMNVSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIGAHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRYMALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVPFPLDNNKSKP GGWLPVEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHEDPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKAKGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSKLTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH |
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
IL17RB Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 514 amino acids (18-292a.a) and having a molecular mass of 57.2kDa (Migrates at 50-70kDa on SDS-PAGE under reducing conditions).IL17RB is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:interleukin-17 receptor activity Biological Process: defense response |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRM6 |
| NCBI GenInfo Identifier: | 21263748 |
| NCBI Gene ID: | 55540 |
| NCBI Accession: | Q9NRM6.2 |
| UniProt Secondary Accession: | Q9NRM6,Q9BPZ0, Q9NRL4, Q9NRM5, |
| UniProt Related Accession: | Q9NRM6 |
| Molecular Weight: | 31,773 Da |
| NCBI Full Name: | Interleukin-17 receptor B |
| NCBI Synonym Full Names: | interleukin 17 receptor B |
| NCBI Official Symbol: | IL17RB�� |
| NCBI Official Synonym Symbols: | CRL4; EVI27; IL17BR; IL17RH1�� |
| NCBI Protein Information: | interleukin-17 receptor B |
| UniProt Protein Name: | Interleukin-17 receptor B |
| UniProt Synonym Protein Names: | Cytokine receptor-like 4; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RB�� |
| UniProt Entry Name: | I17RB_HUMAN |
