Description
| Product Name: | Human IL13RA1 Recombinant Protein |
| Product Code: | RPPB0581 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL13RA1 |
| Synonyms: | CD213A1, IL-13Ra, NR404235, Interleukin-13 receptorsubunit alpha-1,IL-13R subunit alpha-1, IL-13R-alpha-1, IL-13RA1, Cancer/testisantigen 19, Cancer/testis antigen 19. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IL13RA1 protein solution (0.5mg/ml) in Phosphate buffersaline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GGGGAAPTET QPPVTNLSVS VENLCTVIWT WNPPEGASSN CSLWYFSHFGDKQDKKIAPE TRRSIEVPLN ERICLQVGSQ CSTNESEKPS ILVEKCISPP EGDPESAVTE LQCIWHNLSYMKCSWLPGRN TSPDTNYTLY YWHRSLEKIH QCENIFREGQ YFGCSFDLTK VKDSSFEQHS VQIMVKDNAGKIKPSFNIVP LTSRVKPDPP HIKNLSFHND DLYVQWENPQ NFISRCLFYE VEVNNSQTET HNVFYVQEAKCENPEFERNV ENTSCFMVPG VLPDTLNTVR IRVKTNKLCY EDDKLWSNWS QEMSIGKKRN STHHHHHH |
Interleukin-13 receptor subunit alpha-1 (IL13RA1) is a subunit of the interleukin 13 receptor. The IL13RA1 subunit forms a receptor complex with IL4 receptor alpha, which is a subunit shared by IL13 and IL4 receptors. IL13RA1 binds tyrosine kinase TYK2, and thus may mediate the signaling processes which leads to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1 is vital for allergen-induced airway hyperactivity and mucus hypersecretion.
IL13RA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 328 amino acids (22-343 a.a) and having a molecular mass of 37.7kDa (Migrates at 40-57kDa on SDS�PAGE under reducing conditions).IL13RA1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL13R: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xq24 Cellular Component: interleukin-13 receptor complex; plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding Biological Process: cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78552 |
| NCBI GenInfo Identifier: | 2494718 |
| NCBI Gene ID: | 3597 |
| NCBI Accession: | P78552.1 |
| UniProt Secondary Accession: | P78552,O95646, Q5JSL4, Q99656, Q9UDY5, |
| UniProt Related Accession: | P78552 |
| Molecular Weight: | 31,659 Da |
| NCBI Full Name: | Interleukin-13 receptor subunit alpha-1 |
| NCBI Synonym Full Names: | interleukin 13 receptor subunit alpha 1 |
| NCBI Official Symbol: | IL13RA1�� |
| NCBI Official Synonym Symbols: | NR4; CT19; CD213A1; IL-13Ra�� |
| NCBI Protein Information: | interleukin-13 receptor subunit alpha-1 |
| UniProt Protein Name: | Interleukin-13 receptor subunit alpha-1 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 19; CT19; CD_antigen: CD213a1 |
| Protein Family: | Interleukin-13 receptor |
| UniProt Gene Name: | IL13RA1�� |
| UniProt Entry Name: | I13R1_HUMAN |
