Description
| Product Name: | Human HSPB2 Recombinant Protein |
| Product Code: | RPPB5252 |
| Size: | 20µg |
| Species: | Human |
| Target: | HSPB2 |
| Synonyms: | Heat shock 27kDa protein 2, DMPK-binding protein, MKBP, HSP27, LOH11CR1K. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HSPB2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSGRSV PHAHPATAEY EFANPSRLGE QRFGEGLLPE EILTPTLYHG YYVRPRAAPA GEGSRAGASE LRLSEGKFQA FLDVSHFTPD EVTVRTVDNL LEVSARHPQR LDRHGFVSRE FCRTYVLPAD VDPWRVRAAL SHDGILNLEA PRGGRHLDTE VNEVYISLLP APPDPEEEEE AAIVEP |
Heat shock protein beta-2 (HSPB2) is a member of the small heat shock protein (HSP20) family. HSPB2 is a regulator of DMPK kinase.
HSPB2 Human Recombinant produced in�E. coli is a single polypeptide chain containing 206 amino acids (1-182) and having a molecular mass of 22.8kDa.HSPB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HSPB2: May regulate the kinase DMPK. Belongs to the small heat shock protein (HSP20) family. |
| UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 11q22-q23 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:enzyme activator activity; protein binding Biological Process: positive regulation of catalytic activity; response to heat; response to unfolded protein; somatic muscle development |
| NCBI Summary: | The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q16082 |
| NCBI GenInfo Identifier: | 6016268 |
| NCBI Gene ID: | 3316 |
| NCBI Accession: | Q16082.2 |
| UniProt Secondary Accession: | Q16082,Q6I9U7, |
| UniProt Related Accession: | Q16082 |
| Molecular Weight: | 20,233 Da |
| NCBI Full Name: | Heat shock protein beta-2 |
| NCBI Synonym Full Names: | heat shock protein family B (small) member 2 |
| NCBI Official Symbol: | HSPB2�� |
| NCBI Official Synonym Symbols: | MKBP; HSP27; Hs.78846; LOH11CR1K�� |
| NCBI Protein Information: | heat shock protein beta-2 |
| UniProt Protein Name: | Heat shock protein beta-2 |
| UniProt Synonym Protein Names: | DMPK-binding protein; MKBP |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSPB2�� |
| UniProt Entry Name: | HSPB2_HUMAN |
