Description
| Product Name: | Human HRSP12 Recombinant Protein |
| Product Code: | RPPB3719 |
| Size: | 20µg |
| Species: | Human |
| Target: | HRSP12 |
| Synonyms: | Ribonuclease UK114, 14.5 kDa translational inhibitor protein, p14.5, Heat-responsive protein 12, UK114 antigen homolog, HRSP12, PSP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HRSP12 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR IEIEAVAIQG PLTTASL |
HRSP12 (UK114) is an endoribonuclease found mainly in the human adult kidney and liver, and which is responsible for inhibiting translation by cleaving mRNA. HRSP12 cleaves phosphodiester bonds only in single-stranded RNA. HRSP12 may be an important biomarker for heptatic carcinoma.
HRSP12 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 157 amino acids (1-137 a.a.) and having a molecular mass of 16.6kDa. The HRSP12 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HRSP12: Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA. Belongs to the RutC family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.-.- Chromosomal Location of Human Ortholog: 8q22 Cellular Component: mitochondrion; cytoplasm; nucleus Molecular Function:endonuclease activity; deaminase activity Biological Process: regulation of translational termination |
| UniProt Code: | P52758 |
| NCBI GenInfo Identifier: | 1717975 |
| NCBI Gene ID: | 10247 |
| NCBI Accession: | P52758.1 |
| UniProt Related Accession: | P52758 |
| Molecular Weight: | 14 kDa |
| NCBI Full Name: | 2-iminobutanoate/2-iminopropanoate deaminase |
| NCBI Synonym Full Names: | reactive intermediate imine deaminase A homolog |
| NCBI Official Symbol: | RIDA�� |
| NCBI Official Synonym Symbols: | PSP; P14.5; UK114; HRSP12; hp14.5�� |
| NCBI Protein Information: | 2-iminobutanoate/2-iminopropanoate deaminase |
| UniProt Protein Name: | Ribonuclease UK114 |
| UniProt Synonym Protein Names: | 14.5 kDa translational inhibitor protein; p14.5; Heat-responsive protein 12; UK114 antigen homolog |
| Protein Family: | Reactive Intermediate Deaminase |
| UniProt Gene Name: | HRSP12�� |
| UniProt Entry Name: | UK114_HUMAN |
