Description
| Product Name: | Human HNRNPAB Recombinant Protein |
| Product Code: | RPPB5895 |
| Size: | 10µg |
| Species: | Human |
| Target: | HNRNPAB |
| Synonyms: | Heterogeneous Nuclear Ribonucleoprotein A/B, ABBP-1, ABBP1,APOBEC1-Binding Protein 1, HnRNP A/B, Apobec-1 Binding Protein 1, ApolipoproteinB MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1, HnRNP TypeA/B Protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | HNRNPABprotein solution (0.25mg/ml) containing 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSEAGEE QPMETTGATE NGHEAVPEGE SPAGAGTGAA AGAGGATAAP PSGNQNGAEGDQINASKNEE DAGKMFVGGL SWDTSKKDLK DYFTKFGEVV DCTIKMDPNT GRSRGFGFIL FKDAASVEKVLDQKEHRLDG RVIDPKKAMA MKKDPVKKIF VGGLNPEATE EKIREYFGEF GEIEAIELPM DPKLNKRRGF VFITFKEEEPVKKVLEKKFH TVSGSKCEIK VAQPKEVYQQ QQYGSGGRGN RNRGNRGSGG GGGGGGQGST NYGKSQRRGGHQNNYKPY |
Heterogeneous Nuclear Ribonucleoprotein A/B(HNRNPAB) is a member of the subfamily of ubiquitously expressed heterogeneousnuclear ribonucleoproteins(hnRNPs). The hnRNPs are produced by RNA polymerase II and are components oftheheterogeneous nuclear RNA (hnRNA) complexes. They are linked with pre-mRNAsin the nucleus and seem to influence pre-mRNA processing and further aspects ofmRNA metabolism and transport. Whereas all of the hnRNPs are present in the nucleus, some seem toshuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinctnucleic acid binding properties. HNRNPAB, which binds to one of the componentsof the multiprotein editosomecomplex, has two repeats of quasi-RRM (RNA recognition motif) domains that bindto RNAs. Among the diseases associated with HNRNPABare wells syndrome, and cystic fibrosis.
HNRNPAB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285 a.a) and having a molecular mass of 33kDa.HNRNPAB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | hnRNP A/B: a single-stranded RNA binding protein with two RNA-recognition (RRM) domains. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Interacts with APOBEC1. Observed in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. A member of the RNA recognition motif (RRM) family. Four isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex Molecular Function:mRNA binding; RNA binding; sequence-specific DNA binding; nucleotide binding; transcription factor activity Biological Process: positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99729 |
| NCBI GenInfo Identifier: | 158523286 |
| NCBI Gene ID: | 3182 |
| NCBI Accession: | Q99729.2 |
| UniProt Related Accession: | Q99729 |
| Molecular Weight: | |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein A/B |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein A/B |
| NCBI Official Symbol: | HNRNPAB�� |
| NCBI Official Synonym Symbols: | ABBP1; HNRPAB�� |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein A/B |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein A/B |
| UniProt Synonym Protein Names: | APOBEC1-binding protein 1 |
| Protein Family: | Ribosomal operon-associated A protein |
| UniProt Gene Name: | HNRNPAB�� |
| UniProt Entry Name: | ROAA_HUMAN |
