Description
| Product Name: | Human GTF3C6 Recombinant Protein |
| Product Code: | RPPB3608 |
| Size: | 10µg |
| Species: | Human |
| Target: | GTF3C6 |
| Synonyms: | bA397G5.3, C6orf51, TFIIIC35, General transcriptionfactor 3C polypeptide 6, Transcription factor IIIC 35 kDa subunit, TFIIIC 35kDa subunit, TFIIIC35, Transcription factor IIIC subunit 6, CDA020, NPD020. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | GTF3C6 protein solution (0.5mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAAADE RSPEDGEDEE EEEQLVLVEL SGIIDSDFLS KCENKCKVLG IDTERPILQVDSCVFAGEYE DTLGTCVIFE ENVEHADTEG NNKTVLKYKC HTMKKLSMTR TLLTEKKEGE ENIGGVEWLQIKDNDFSYRP NMICNFLHEN EDEEVVASAP DKSLELEEEE IQMNDSSNLS CEQEKPMHLE IEDSGPLIDIPSETEGSVFM ETQMLP |
In the absence of additional proteins - the general transcription factors (GTFs) RNA polymerases are unable to initiate RNA synthesis. GTFs accumulate in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are vital for RNA polymerase III to produce several small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.
GTF3C6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-213 a.a) and having a molecular mass of 26.4kDa.GTF3C6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GTF3C6: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Belongs to the TFIIIC subunit 6 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleoplasm; transcription factor TFIIIC complex Molecular Function:DNA binding; protein binding Biological Process: 5S class rRNA transcription; transcription from RNA polymerase III promoter; transcription, DNA-dependent; tRNA transcription from RNA polymerase III promoter |
| UniProt Code: | Q969F1 |
| NCBI GenInfo Identifier: | 19923927 |
| NCBI Gene ID: | 112495 |
| NCBI Accession: | NP_612417.1 |
| UniProt Secondary Accession: | Q969F1,Q5VXN2, |
| UniProt Related Accession: | Q969F1 |
| Molecular Weight: | 24,049 Da |
| NCBI Full Name: | general transcription factor 3C polypeptide 6 |
| NCBI Synonym Full Names: | general transcription factor IIIC subunit 6 |
| NCBI Official Symbol: | GTF3C6�� |
| NCBI Official Synonym Symbols: | C6orf51; TFIIIC35; bA397G5.3�� |
| NCBI Protein Information: | general transcription factor 3C polypeptide 6 |
| UniProt Protein Name: | General transcription factor 3C polypeptide 6 |
| UniProt Synonym Protein Names: | Transcription factor IIIC 35 kDa subunit; TFIIIC 35 kDa subunit; TFIIIC35; Transcription factor IIIC subunit 6 |
| Protein Family: | General transcription factor 3C polypeptide |
| UniProt Gene Name: | GTF3C6�� |
| UniProt Entry Name: | TF3C6_HUMAN |
