Description
| Product Name: | Human GRPEL1 Recombinant Protein |
| Product Code: | RPPB3644 |
| Size: | 10µg |
| Species: | Human |
| Target: | GRPEL1 |
| Synonyms: | HMGE, GrpE-like protein cochaperone, GREPEL1, FLJ25609. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GRPEL1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCTATKQKNS GQNLEEDMGQ SEQKADPPAT EKTLLEEKVK LEEQLKETVE KYKRALADTE NLRQRSQKLV EEAKLYGIQA FCKDLLEVAD VLEKATQCVP KEEIKDDNPH LKNLYEGLVM TEVQIQKVFT KHGLLKLNPV GAKFDPYEHE ALFHTPVEGK EPGTVALVSK VGYKLHGRTL RPALVGVVKE A |
GRPEL1 is a vital component of the PAM complex, a complex necessary for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. GRPEL1 protein controls the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
GRPEL1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (28-217a.a.) and having a molecular mass of 23.6kDa.GRPEL1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GRPEL1: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Belongs to the GrpE family. |
| UniProt Protein Details: | Protein type:Chaperone; Mitochondrial Chromosomal Location of Human Ortholog: 4p16 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein homodimerization activity; adenyl-nucleotide exchange factor activity; chaperone binding; unfolded protein binding Biological Process: cellular protein metabolic process; protein folding; regulation of catalytic activity; protein targeting to mitochondrion |
| UniProt Code: | Q9HAV7 |
| NCBI GenInfo Identifier: | 18202951 |
| NCBI Gene ID: | 80273 |
| NCBI Accession: | Q9HAV7.2 |
| UniProt Secondary Accession: | Q9HAV7,Q549M6, B2R783, |
| UniProt Related Accession: | Q9HAV7 |
| Molecular Weight: | 24,279 Da |
| NCBI Full Name: | GrpE protein homolog 1, mitochondrial |
| NCBI Synonym Full Names: | GrpE-like 1, mitochondrial (E. coli) |
| NCBI Official Symbol: | GRPEL1�� |
| NCBI Official Synonym Symbols: | HMGE�� |
| NCBI Protein Information: | grpE protein homolog 1, mitochondrial; GrpE-like protein cochaperone; mt-GrpE#1 |
| UniProt Protein Name: | GrpE protein homolog 1, mitochondrial |
| UniProt Synonym Protein Names: | HMGE; Mt-GrpE#1 |
| Protein Family: | GrpE protein |
| UniProt Gene Name: | GRPEL1�� |
| UniProt Entry Name: | GRPE1_HUMAN |
