Description
system_update_altDatasheet
| Product name | Human GPR75 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP014 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | GPR75 |
| Uniprot: | O95800 |
| Description: | Human GPR75 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length GPR75 protein has a MW of 59.4 kDa |
| Protein Family: | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways: | |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | GPRchr2; WI31133 |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. |
| Delivery: | In Stock |
| Usage | Research use only |
