Description
| Product Name: | Human GNPDA1 Recombinant Protein |
| Product Code: | RPPB1719 |
| Size: | 20µg |
| Species: | Human |
| Target: | GNPDA1 |
| Synonyms: | GNP1, GNPDA, GNPI, GPI, HLN, Oscillin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 1 mg/ml solution containing 20mM Tris Hcl buffer pH-8, 1mM DTT, 50mM NaCl and 20% glycerol. |
| Stability: | GNPDA1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK KLIEYYKNGD LSFKYVKTFNMDEYVGLPRD HPESYHSFMW NNFFKHIDIH PENTHILDGN AVDLQAECDA FEEKIKAAGG IELFVGGIGP DGHIAFNEPG SSLVSRTRVK TLAMDTILAN ARFFDGELTK VPTMALTVGV GTVMDAREVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD EDATLELKVKTVKYFKGLML VHNKLVDPLY SIKEKETEKS QSSKKPYSD |
GNPDA1, catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate. GNPDA1 is widely expressed with highest expression in testes, ovary and heart. GNPDA1 triggers calcium oscillations in mammalian eggs. These oscillations are as the necessary trigger for egg activation and early development of the embryo.
GNPDA1 Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 309 amino acids (1-289) and having a molecular mass of 34.8 kDa.GNPDA1 is fused to a 20 amino macid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GNPDA1: Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - amino sugar and nucleotide sugar; Isomerase; EC 3.5.99.6; Hydrolase Chromosomal Location of Human Ortholog: 5q21 Cellular Component: cytoplasm Molecular Function:glucosamine-6-phosphate deaminase activity; hydrolase activity Biological Process: generation of precursor metabolites and energy; single fertilization; N-acetylglucosamine metabolic process; carbohydrate metabolic process; glucosamine catabolic process |
| NCBI Summary: | Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010] |
| UniProt Code: | P46926 |
| NCBI GenInfo Identifier: | 1171639 |
| NCBI Gene ID: | 10007 |
| NCBI Accession: | P46926.1 |
| UniProt Related Accession: | P46926 |
| Molecular Weight: | Observed: 33 kDaPredicted: 33 kDa |
| NCBI Full Name: | Glucosamine-6-phosphate isomerase 1 |
| NCBI Synonym Full Names: | glucosamine-6-phosphate deaminase 1 |
| NCBI Official Symbol: | GNPDA1�� |
| NCBI Official Synonym Symbols: | GPI; HLN; GNP1; GNPI; GNPDA�� |
| NCBI Protein Information: | glucosamine-6-phosphate isomerase 1 |
| UniProt Protein Name: | Glucosamine-6-phosphate isomerase 1 |
| UniProt Synonym Protein Names: | Glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; Oscillin |
| Protein Family: | Glucosamine-6-phosphate isomerase |
| UniProt Gene Name: | GNPDA1�� |
| UniProt Entry Name: | GNPI1_HUMAN |
