Description
| Product Name: | Nanodisc Human GLP1R-Strep Protein |
| SKU: | HDFP857 |
| Size: | 10μg |
| Target: | GLP1R |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | GLP-1; GLP-1-R; GLP-1R |
| Protein Families: | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane. |
| Protein Description: | Human GLP1R-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Neuroactive ligand-receptor interaction. |
| Molecular Weight: | The human full length GLP1R-Strep protein has a MW of 53 kDa |
A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
| Uniprot ID: | P43220 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
