Description
| Product Name: | Human GIPC1 Recombinant Protein |
| Product Code: | RPPB3596 |
| Size: | 10µg |
| Species: | Human |
| Target: | GIPC1 |
| Synonyms: | PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1, NIP, GIPC, IIP-1, SEMCAP, Hs.6454, MGC3774, GLUT1CBP, MGC15889. SYNECTIN, SYNECTIIN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | GIPC1 Human solution (0.5mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl, 1mM EDTA & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY |
GIPC1 is a PDZ domain protein that cooperates with RGS-GAIP and the viral oncoprotein TAX, which transactivates viral and cellular promoters throughout interactions with different transcription factors. GIPC1 particularly localizes to clusters of vesicles close to the plasma membrane and takes part in G protein-coupled signaling pathway participating in regulating Clathrin-coated vesicular trafficking. GIPC1 cooperates with membrane bound Semaphorin F, which is takes part in neuronal axon growth, and controls the subcellular distribution of M-SemF in the brain.
GIPC1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids (1-333 a.a) and having a molecular mass of 38.2kDa. The GIPC1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GIPC1: May be involved in G protein-linked signaling. Belongs to the GIPC family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAP; GAP, misc.; Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: cell cortex; cytoplasm; cytoplasmic vesicle; cytosol; dendritic shaft; dendritic spine; membrane; synaptic vesicle; vesicle membrane Molecular Function:actin binding; cadherin binding; myosin binding; protein binding; protein homodimerization activity; receptor binding Biological Process: endothelial cell migration; glutamate secretion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cytokinesis; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting; regulation of protein stability; regulation of synaptic plasticity; synaptic transmission |
| NCBI Summary: | GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009] |
| UniProt Code: | O14908 |
| NCBI GenInfo Identifier: | 17375873 |
| NCBI Gene ID: | 10755 |
| NCBI Accession: | O14908.2 |
| UniProt Secondary Accession: | O14908,Q9BTC9, A8K4I3, A8MZG3, |
| UniProt Related Accession: | O14908 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | PDZ domain-containing protein GIPC1 |
| NCBI Synonym Full Names: | GIPC PDZ domain containing family member 1 |
| NCBI Official Symbol: | GIPC1�� |
| NCBI Official Synonym Symbols: | NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN�� |
| NCBI Protein Information: | PDZ domain-containing protein GIPC1 |
| UniProt Protein Name: | PDZ domain-containing protein GIPC1 |
| UniProt Synonym Protein Names: | GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; Tax interaction protein 2; TIP-2 |
| Protein Family: | PDZ domain-containing protein |
| UniProt Gene Name: | GIPC1�� |
