Description
| Product Name: | Human GHRH Recombinant Protein |
| Product Code: | RPPB1311 |
| Size: | 1mg |
| Species: | Human |
| Target: | GHRH |
| Synonyms: | Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH, Somatocrinin, Somatorelin, Sermorelin, GHRF, MGC119781. |
| Source: | Synthetic |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The GHRH peptide (1mg/ml) was lyophilized after extensive dialyses against 1.7 mg sodium phosphate buffer (0.1 mg sodium phosphate monobasic & 1.6 mg sodium phosphate dibasic). |
| Solubility: | It is recommended to reconstitute the lyophilized GHRH in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. The GHRH is also soluble in 1% Acetic acid at a concentration of >1mg/ml to give a clear, colorless solution. |
| Stability: | Lyophilized Growth Hormone Releasing Hormone although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHRF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The free base of sermorelin has the empirical formula C149H246N 44O42STyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Biological Activity: | GHRH increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone. |
Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acidpeptide hormoneproduced in the arcuate nucleusof the hypothalamus.GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary glandwhere it stimulates growth hormone(GH) secretion. GHRH also stimulates the production of GH. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleepdirectly.
Growth Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3358.9 Dalton.Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting of 44 amino acid residues.The GHRH is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: extracellular space; extracellular region; terminal button Molecular Function:growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01286 |
| NCBI GenInfo Identifier: | 134521 |
| NCBI Gene ID: | 2691 |
| NCBI Accession: | P01286.1 |
| UniProt Secondary Accession: | P01286,Q4KN10, Q5JYR1, |
| UniProt Related Accession: | P01286 |
| Molecular Weight: | 108 |
| NCBI Full Name: | Somatoliberin |
| NCBI Synonym Full Names: | growth hormone releasing hormone |
| NCBI Official Symbol: | GHRH�� |
| NCBI Official Synonym Symbols: | GRF; INN; GHRF�� |
| NCBI Protein Information: | somatoliberin; sermorelin; somatorelin; somatocrinin; growth hormone-releasing factor; growth hormone-releasing hormone |
| UniProt Protein Name: | Somatoliberin |
| UniProt Synonym Protein Names: | Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin |
| Protein Family: | Somatoliberin |
| UniProt Gene Name: | GHRH�� |
| UniProt Entry Name: | SLIB_HUMAN |
| Iga ZendranIga et al. | Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review | Frontiers in Endocrinology 2022 | PubMed ID: 35757397 |
