Description
| Product Name: | Human GDF10 Recombinant Protein |
| Product Code: | RPPB0309 |
| Size: | 20µg |
| Species: | Human |
| Target: | GDF10 |
| Synonyms: | Bone morphogenetic protein 3b, BMP-3b, Growth/differentiation factor 10, GDF-10, Bone-inducing protein, BIP, GDF10, BMP3B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GDF10 solution (1mg/ml) contains 10mM Sodium citrate (pH 3.5), 1mM DTT, 40% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQWDEPRVCS RRYLKVDFAD IGWNEWIISP KSFDAYYCAG ACEFPMPKIV RPSNHATIQS IVRAVGIIPG IPEPCCVPDK MNSLGVLFLD ENRNVVLKVY PNMSVDTCAC R |
GDF10 is a member of the BMP family and the TGF-beta superfamily. GDF10 is expressed in femur, brain, lung, skeletal, muscle, pancreas and testis, and has a role in head formation and possibly multiple roles in skeletal morphogenesis. In humans, GDF10 mRNA is found in the cochlea and lung of fetuses, and in testis, retina, pineal gland, and other neural tissues of adults. The BMP family members are regulators of cell growth and differentiation in both embryonic and adult tissues. These proteins are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing 7 conserved cysteine residues.
GDF10 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids (369-478 a.a.) and having a total molecular mass of 12.5 kDa. GDF10 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GDF10: is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q11.22 Cellular Component: extracellular space Molecular Function:cytokine activity; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; cell development; negative regulation of osteoblast differentiation; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P55107 |
| NCBI GenInfo Identifier: | 1705471 |
| NCBI Gene ID: | 2662 |
| NCBI Accession: | P55107.1 |
| UniProt Secondary Accession: | P55107,Q5VSQ8, Q9UCX6, |
| UniProt Related Accession: | P55107 |
| Molecular Weight: | 53kDa |
| NCBI Full Name: | Growth/differentiation factor 10 |
| NCBI Synonym Full Names: | growth differentiation factor 10 |
| NCBI Official Symbol: | GDF10�� |
| NCBI Official Synonym Symbols: | BIP; BMP3B; BMP-3b�� |
| NCBI Protein Information: | growth/differentiation factor 10 |
| UniProt Protein Name: | Growth/differentiation factor 10 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 3B; BMP-3B; Bone-inducing protein; BIP |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF10�� |
