Description
| Product Name: | Human GCSAM Recombinant Protein |
| Product Code: | RPPB3583 |
| Size: | 20µg |
| Species: | Human |
| Target: | GCSAM |
| Synonyms: | GCAT2, HGAL, Germinal center-associated signaling and motility protein, Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, GAL, GCET2 . |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GCSAM solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGNSLLR ENRRQQNTQE MPWNVRMQSP KQRTSRCWDH HIAEGCFCLP WKKILIFEKR QDSQNENERM SSTPIQDNVD QTYSEELCYT LINHRVLCTR PSGNSAEEYY ENVPCKAERP RESLGGTETE YSLLHMPSTD PRHARSPEDE YELLMPHRIS SHFLQQPRPL MAPSETQFSH L |
GCSAM is a protein which functions in signal transduction pathways and whose expression raises in germinal cell lymphomas. GCSAM contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, GCSAM expression is particularly induced by interleukin-4.
GCSAM Human Recombinant produced in E. coli is a single polypeptide chain containing 201 amino acids (1-178) and having a molecular mass of 23 kDa. GCSAM is fused to 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GCET2: a protein expressed in normal germinal center B cells, immature B and T cells. Induced by IL4. Its expression strongly predicts survival in diffuse large B-cell lymphoma. Protein type: Unknown functionChromosomal Location of Human Ortholog: 3q13.2Molecular Function: actin binding; myosin II binding; protein binding; protein kinase bindingBiological Process: regulation of B cell receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N6F7 |
| NCBI GenInfo Identifier: | 74729123 |
| NCBI Gene ID: | 257144 |
| NCBI Accession: | Q8N6F7.1 |
| UniProt Secondary Accession: | Q8N6F7,C9JD17, C9JUG6 |
| UniProt Related Accession: | Q8N6F7 |
| Molecular Weight: | 19,206 Da |
| NCBI Full Name: | Germinal center-associated signaling and motility protein |
| NCBI Synonym Full Names: | germinal center associated signaling and motility |
| NCBI Official Symbol: | GCSAM�� |
| NCBI Official Synonym Symbols: | HGAL; GCAT2; GCET2�� |
| NCBI Protein Information: | germinal center-associated signaling and motility protein |
| UniProt Protein Name: | Germinal center-associated signaling and motility protein |
| UniProt Synonym Protein Names: | Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL |
| Protein Family: | |
| UniProt Gene Name: | GCSAM�� |
| UniProt Entry Name: |
