Description
| Product Name: | Nanodisc Human FZD7-Strep Protein |
| SKU: | HDFP845 |
| Size: | 10μg |
| Target: | FZD7 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | FzE3 |
| Protein Families: | Druggable Genome, Transmembrane. |
| Protein Description: | Human FZD7-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway. |
| Molecular Weight: | The human full length FZD7-Strep protein has a MW of 63.6 kDa |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
| Uniprot ID: | O75084 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C(Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
