Description
| Product Name: | Human FTH1 Recombinant Protein |
| Product Code: | RPPB3533 |
| Size: | 25µg |
| Species: | Human |
| Target: | FTH1 |
| Synonyms: | Ferritin heavy chain, Cell proliferation-inducing gene 15 protein, FTH1, FHC, FTH, PLIF, FTHL6, PIG15, MGC104426. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The FTH1 protein solution contains 20mM Tris-HCl pH-7.5, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES |
Ferritin is a fairly large, iron-storage heteropolymeric protein composed of 2 subunit types, light Ferritin & heavy Ferritin polypeptides, which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin is composed of 24 self-assembled polypeptide subunits of the heavy and light ferritin chains and is characterized by the capacity to remove Fe (II) from solution in the presence of oxygen. Ferritin light polypeptide protein is the main intracellular iron storage protein in prokaryotes and eukaryotes. Variation in ferritin subunit composition influence the rates of iron uptake and release in various tissues. A key function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyper ferrit anemia-cataract syndrome. Ferritin stores iron in a soluble, nontoxic, readily accessible form. Ferritin is needed for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after it has been oxidized.
FTH1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids and having a molecular mass of 21 kDa.
| UniProt Protein Function: | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. |
| NCBI Summary: | This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02794 |
| NCBI GenInfo Identifier: | 120516 |
| NCBI Gene ID: | 2495 |
| NCBI Accession: | P02794.2 |
| UniProt Secondary Accession: | P02794,Q3KRA8, Q3SWW1, B3KNR5, |
| UniProt Related Accession: | P02794 |
| Molecular Weight: | |
| NCBI Full Name: | Ferritin heavy chain |
| NCBI Synonym Full Names: | ferritin, heavy polypeptide 1 |
| NCBI Official Symbol: | FTH1�� |
| NCBI Official Synonym Symbols: | FHC; FTH; HFE5; PLIF; FTHL6; PIG15�� |
| NCBI Protein Information: | ferritin heavy chain |
| UniProt Protein Name: | Ferritin heavy chain |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 15 protein |
| Protein Family: | Iron transporter |
| UniProt Gene Name: | FTH1�� |
| UniProt Entry Name: | FRIH_HUMAN |
