Description
| Product Name: | Human FOSL2 Recombinant Protein |
| Product Code: | RPPB3554 |
| Size: | 10µg |
| Species: | Human |
| Target: | FOSL2 |
| Synonyms: | FOS-Like Antigen 2, FRA-2, FRA2, Fos-Related Antigen 2, FOSL2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | FOSL2 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMYQDYPG NFDTSSRGSS GSPAHAESYS SGGGGQQKFR VDMPGSGSAF IPTINAITTS QDLQWMVQPT VITSMSNPYP RSHPYSPLPG LASVPGHMAL PRPGVIKTIG TTVGRRRRDE QLSPEEEEKR RIRRERNKLA AAKCRNRRRE LTEKLQAETE ELEEEKSGLQ KEIAELQKEK EKLEFMLVAH GPVCKISPEE RRSPPAPGLQ PMRSGGGSVG AVVVKQEPLE EDSPSSSSAG LDKAQRSVIK PISIAGGFYG EEPLHTPIVV TSTPAVTPGT SNLVFTYPSV LEQESPASPS ESCSKAHRRS SSSGDQSSDS LNSPTLLAL |
FOS-LikeAntigen 2, also known as FOSL2 is a protein which is encoded in humans by theFOSL2 gene. The Fos gene family consists of four members: FOS, FOSB, FOSL1, andFOSL2. Furthermore, these genes encode leucine zipper proteins which candimerize with proteins of the JUN family, in that way forming the transcriptionfactor complex AP-1. As such, the FOS proteins have been involved as regulatorsof cell proliferation, differentiation, as well transformation.
FOSL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-326 a.a) and having a molecular mass of 37.6kDa.FOSL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FRA2: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA2 and JUND up-regulate the expression of CCR4, MYB, MDM2, and BCL6, and are expressed at high levels in CCR4-expressing mature T-cell malignancies such as adult T-cell leukemia/lymphoma (ATLL) and cutaneous T-cell lymphomas (CTCLs). May play a role in regulating the transcription of ICOS downstream of TCR/CD28 and cytokine receptor signaling. Its transcription is significantly increased in metastatic clear cell renal cell carcinomas. Belongs to the bZIP family, Fos subfamily. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: cell death; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P15408 |
| NCBI GenInfo Identifier: | 120487 |
| NCBI Gene ID: | 2355 |
| NCBI Accession: | P15408.1 |
| UniProt Secondary Accession: | P15408,Q6FG46, B2RD58, B3KP27, B4DYV4, |
| UniProt Related Accession: | P15408 |
| Molecular Weight: | 31,095 Da |
| NCBI Full Name: | Fos-related antigen 2 |
| NCBI Synonym Full Names: | FOS like 2, AP-1 transcription factor subunit |
| NCBI Official Symbol: | FOSL2�� |
| NCBI Official Synonym Symbols: | FRA2�� |
| NCBI Protein Information: | fos-related antigen 2 |
| UniProt Protein Name: | Fos-related antigen 2 |
| Protein Family: | Fos-related antigen |
| UniProt Gene Name: | FOSL2�� |
| UniProt Entry Name: | FOSL2_HUMAN |
