Human FIBP Recombinant Protein (RPPB0254)

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SKU:
RPPB0254
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43427
Research Area:
Growth Factors & Cytokines
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Description

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Product Name:Human FIBP Recombinant Protein
Product Code:RPPB0254
Size:10µg
Species:Human
Target:FIBP
Synonyms:FGFIBP, FIBP-1, Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein, FIBP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FIBP protein (0.5mg/ml) is supplied in 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMTSELDI FVGNTTLIDE DVYRLWLDGY SVTDAVALRV RSGILEQTGA TAAVLQSDTM DHYRTFHMLE RLLHAPPKLL HQLIFQIPPS RQALLIERYY AFDEAFVREV LGKKLSKGTK KDLDDISTKT GITLKSCRRQ FDNFKRVFKV VEEMRGSLVD NIQQHFLLSD RLARDYAAIV FFANNRFETG KKKLQYLSFG DFAFCAELMI QNWTLGAVGE APTDPDSQMD DMDMDLDKEF LQDLKELKVL VADKDLLDLH KSLVCTALRG KLGVFSEMEA NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV EKFVEPCRSD HWPLSDVRFF LNQYSASVHS LDGFRHQALW DRYMGTLRGC LLRLYHD

FGF-1 Intracellular-Binding Protein (FIBP) which is a member of Fibroblast growth factors (FGFs) binds to internalized FGF-1 and is thought to be involved in mitogenic function of FGF-1. FGF activity effects development, adult tissue homeostasis, angiogenesis and cancer progression. FIBP localizes to the nucleus and is greatly expressed in heart, skeletal muscle and pancreas and at lower levels in brain, placenta, liver and kidney.

FIBP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 387amino acids (1-364) and having a molecular mass of 44.3kDa. The FIBP is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:FIBP: May be involved in mitogenic function of FGF1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: nucleoplasm; membrane; mitochondrion; endomembrane system; nucleus

Molecular Function:fibroblast growth factor binding

Biological Process: fibroblast growth factor receptor signaling pathway

NCBI Summary:Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O43427
NCBI GenInfo Identifier:13431517
NCBI Gene ID:9158
NCBI Accession:O43427.3
UniProt Secondary Accession:O43427,Q27Q85, Q6IBQ3, Q9HD65, A8K0J7,
UniProt Related Accession:O43427
Molecular Weight:364
NCBI Full Name:Acidic fibroblast growth factor intracellular-binding protein
NCBI Synonym Full Names:fibroblast growth factor (acidic) intracellular binding protein
NCBI Official Symbol:FIBP��
NCBI Official Synonym Symbols:FGFIBP; FIBP-1��
NCBI Protein Information:acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein; FGF-1 intracellular-binding protein
UniProt Protein Name:Acidic fibroblast growth factor intracellular-binding protein
UniProt Synonym Protein Names:FGF-1 intracellular-binding protein
Protein Family:Acidic fibroblast growth factor intracellular-binding protein
UniProt Gene Name:FIBP��
UniProt Entry Name:FIBP_HUMAN
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