Description
| Product Name: | Human FAAH2 Recombinant Protein |
| Product Code: | RPPB1628 |
| Size: | 25µg |
| Species: | Human |
| Target: | FAAH2 |
| Synonyms: | Fatty acid amide hydrolase 2, AMDD, Amidase domain-containing protein, Anandamide amidohydrolase 2, Oleamide hydrolase 2, FAAH2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The FAAH2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSGGPKFAS KTPRPVTEPL LLLSGMQLAK LIRQRKVKCI DVVQAYINRI KDVNPMINGI VKYRFEEAMK EAHAVDQKLA EKQEDEATLE NKWPFLGVPL TVKEAFQLQG MPNSSGLMNR RDAIAKTDAT VVALLKGAGA IPLGITNCSE LCMWYESSNK IYGRSNNPYD LQHIVGGSSG GEGCTLAAAC SVIGVGSDIG GSIRMPAFFN GIFGHKPSPG VVPNKGQFPL AVGAQELFLC TGPMCRYAED LAPMLKVMAG PGIKRLKLDT KVHLKDLKFY WMEHDGGSFL MSKVDQDLIM TQKKVVVHLE TILGASVQHV KLKKMKYSFQ LWIAMMSAKG HDGKEPVKFV DLLGDHGKHV SPLWELIKWC LGLSVYTIPS IGLALLEEKL RYSNEKYQKF KAVEESLRKE LVDMLGDDGV FLYPSHPTVA PKHHVPLTRP FNFAYTGVFS ALGLPVTQCP LGLNAKGLPL GIQVVAGPFN DHLTLAVAQY LEKTFGGWVC PGKF |
Fatty Acid Amide Hydrolase 2 (FAAH2) shares a conserved protein motif with the amidase signature family of enzymes. FAAH2 catalyzes the hydrolysis of a broad range of bioactive lipids, including those from the 3 main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. FAAH2 is also degrades bioactive fatty acid amides to their corresponding acids, thus helping to end the signaling functions of these molecules. FAAH2 prefers monounsaturated acyl chains as a substrate.��
FAAH2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 524 amino acids (32-532a.a) and having a molecular mass of 57.4kDa. FAAH2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FAAH2: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. Belongs to the amidase family. |
| UniProt Protein Details: | Protein type:EC 3.5.1.99; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp11.21 Cellular Component: lipid particle Molecular Function:fatty acid amide hydrolase activity Biological Process: arachidonic acid metabolic process |
| NCBI Summary: | This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q6GMR7 |
| NCBI GenInfo Identifier: | 74757585 |
| NCBI Gene ID: | 158584 |
| NCBI Accession: | Q6GMR7.1 |
| UniProt Secondary Accession: | Q6GMR7,Q86VT2, Q96N98, |
| UniProt Related Accession: | Q6GMR7 |
| Molecular Weight: | 58,304 Da |
| NCBI Full Name: | Fatty-acid amide hydrolase 2 |
| NCBI Synonym Full Names: | fatty acid amide hydrolase 2 |
| NCBI Official Symbol: | FAAH2�� |
| NCBI Official Synonym Symbols: | AMDD�� |
| NCBI Protein Information: | fatty-acid amide hydrolase 2 |
| UniProt Protein Name: | Fatty-acid amide hydrolase 2 |
| UniProt Synonym Protein Names: | Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2 |
| Protein Family: | Fatty-acid amide hydrolase |
| UniProt Gene Name: | FAAH2�� |
| UniProt Entry Name: | FAAH2_HUMAN |
