Description
| Product Name: | Human ERLIN2 Recombinant Protein |
| Product Code: | RPPB3462 |
| Size: | 20µg |
| Species: | Human |
| Target: | ERLIN2 |
| Synonyms: | Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2,ERLIN2, C8orf2, SPFH2, UNQ2441, PRO5003, PRO9924, NET32, SPG18. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ERLIN2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKIEEGHI GVYYRGGALL TSTSGPGFHL MLPFITSYKS VQTTLQTDEV KNVPCGTSGG VMIYFDRIEV VNFLVPNAVY DIVKNYTADY DKALIFNKIH HELNQFCSVH TLQEVYIELF DQIDENLKLA LQQDLTSMAP GLVIQAVRVT KPNIPEAIRR NYELMESEKT KLLIAAQKQK VVEKEAETER KKALIEAEKV AQVAEITYGQ KVMEKETEKK ISEIEDAAFL AREKAKADAE CYTAMKIAEA NKLKLTPEYL QLMKYKAIAS NSKIYFGKDI PNMFMDSAGS VSKQFEGLAD KLSFGLEDEP LETATKEN� |
ER Lipid Raft Associated 2 (ERLIN2) is a domain-containing protein which is a member of the band 7/mec-2 family. ERLIN2 is a ubiquitously expressed 339 amino acid protein.ERLIN2 which is localized to the lipid raft-like domains in the membrane of the endoplasmic reticulum (ER), plays a key role in the ER-associated degradation (ERAD) pathway that eliminates metabolically regulated and abnormal proteins from the ER.
ERLIN2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (25-339 a.a) and having a molecular mass of 37.8 kDa.ERLIN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SPFH2: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; lipid raft; plasma membrane; protein complex Molecular Function:cholesterol binding; protein binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway Disease: Spastic Paraplegia 18, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O94905 |
| NCBI GenInfo Identifier: | 38257366 |
| NCBI Gene ID: | 11160 |
| NCBI Accession: | O94905.1 |
| UniProt Secondary Accession: | O94905,Q6NW21, Q86VS6, Q86W49, A0JLQ1, A8K5S9, B4DM38 D3DSW0, |
| UniProt Related Accession: | O94905 |
| Molecular Weight: | 22,939 Da |
| NCBI Full Name: | Erlin-2 |
| NCBI Synonym Full Names: | ER lipid raft associated 2 |
| NCBI Official Symbol: | ERLIN2�� |
| NCBI Official Synonym Symbols: | NET32; SPFH2; SPG18; C8orf2; Erlin-2�� |
| NCBI Protein Information: | erlin-2 |
| UniProt Protein Name: | Erlin-2 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2 |
| Protein Family: | Erlin |
| UniProt Gene Name: | ERLIN2�� |
| UniProt Entry Name: | ERLN2_HUMAN |
