Description
| Product Name: | Human EFNB2 Recombinant Protein |
| Product Code: | RPPB3413 |
| Size: | 20µg |
| Species: | Human |
| Target: | EFNB2 |
| Synonyms: | Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L, EFNB2, EPLG5, HTKL, LERK5, MGC126226, MGC126227, MGC126228. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | EFNB2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 200mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMIVLEP IYWNSSNSKF LPGQGLVLYP QIGDKLDIIC PKVDSKTVGQ YEYYKVYMVD KDQADRCTIK KENTPLLNCA KPDQDIKFTI KFQEFSPNLW GLEFQKNKDY YIISTSNGSL EGLDNQEGGV CQTRAMKILM KVGQDASSAG STRNKDPTRR PELEAGTNGR SSTTSPFVKP NPGSSTDGNS AGHSGNNILG SEVALFA |
Ephrin-B2 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated with mediating developmental events, particularly in the nervous system and in erythropoiesis. Based upon their structures and sequence relationships, ephrins are allocated into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Ephrin-B2 binds to the EPHB4 and EPHA3 receptors.
EFNB2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (28-229 a.a.) and having a molecular mass of 24.9kDa.EFNB2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EFNB2: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q33 Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; organ morphogenesis; anatomical structure morphogenesis; regulation of chemotaxis; viral reproduction; cell-cell signaling; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; cell adhesion; lymph vessel development |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52799 |
| NCBI GenInfo Identifier: | 1706673 |
| NCBI Gene ID: | 1948 |
| NCBI Accession: | P52799.1 |
| UniProt Secondary Accession: | P52799,Q5JV56, |
| UniProt Related Accession: | P52799 |
| Molecular Weight: | 333 |
| NCBI Full Name: | Ephrin-B2 |
| NCBI Synonym Full Names: | ephrin-B2 |
| NCBI Official Symbol: | EFNB2�� |
| NCBI Official Synonym Symbols: | HTKL; EPLG5; Htk-L; LERK5�� |
| NCBI Protein Information: | ephrin-B2; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5 |
| UniProt Protein Name: | Ephrin-B2 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNB2�� |
| UniProt Entry Name: | EFNB2_HUMAN |
