Description
| Product Name: | Human EFNA3 Recombinant Protein |
| Product Code: | RPPB3408 |
| Size: | 20µg |
| Species: | Human |
| Target: | EFNA3 |
| Synonyms: | Ephrin-A3, EFL2, Ehk1-L, EPLG3, LERK3, EPH-related receptor tyrosine kinase ligand 3. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Fractalkine solution (0.5 mg/ml) contains 10% Glycerol and Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than�90.0%�as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQGPGGAL GNRHAVYWNS SNQHLRREGY TVQVNVNDYL DIYCPHYNSS GVGPGAGPGPGGGAEQYVLY MVSRNGYRTC NASQGFKRWE CNRPHAPHSP IKFSEKFQRY SAFSLGYEFHAGHEYYYIST PTHNLHWKCL RMKVFVCCAS TSHSGEKPVP TLPQFTMGPN VKINVLEDFEGENPQVPKLE KSISGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEVTCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEYKCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAVEWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHHHHHH� |
EFNA3 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors include the�largest subfamily of receptor protein-tyrosine kinases which have been implicated in mediating developmental events,�especially in the nervous system and in erythropoiesis. Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class, based on their structures and sequence relationships. The Ephrins from the EFNA class are anchored to the membrane by a�glycosylphosphatidylinositol linkage, while the others from the EFNB class are transmembrane proteins.
EFNA3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 434 amino acids (23-214aa) and having a molecular mass of 48.7kDaEFNA3 is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EFNA3: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the ephrin family. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Cell development/differentiation; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: integral to plasma membrane; extracellular region; plasma membrane Molecular Function:ephrin receptor binding; transmembrane-ephrin receptor activity Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52797 |
| NCBI GenInfo Identifier: | 1706671 |
| NCBI Gene ID: | 1944 |
| NCBI Accession: | P52797.1 |
| UniProt Secondary Accession: | P52797,Q0VGC9, Q5SR70, B7ZAD3, D3DV85, |
| UniProt Related Accession: | P52797 |
| Molecular Weight: | 23,575 Da |
| NCBI Full Name: | Ephrin-A3 |
| NCBI Synonym Full Names: | ephrin-A3 |
| NCBI Official Symbol: | EFNA3�� |
| NCBI Official Synonym Symbols: | EFL2; EPLG3; LERK3; Ehk1-L�� |
| NCBI Protein Information: | ephrin-A3; EFL-2; EHK1 ligand; LERK-3; eph-related receptor tyrosine kinase ligand 3; ligand of eph-related kinase 3 |
| UniProt Protein Name: | Ephrin-A3 |
| UniProt Synonym Protein Names: | EFL-2; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNA3�� |
| UniProt Entry Name: | EFNA3_HUMAN |
