Description
| Product Name: | Human DYNLT3 Recombinant Protein |
| Product Code: | RPPB3384 |
| Size: | 10µg |
| Species: | Human |
| Target: | DYNLT3 |
| Synonyms: | Dynein light chain Tctex-type 3, t-complex-associated-testis-expressed 1-like, TCTE1XL, Protein 91/23, TCTEX1L, TCTE1L, RP3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DYNLT3 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEEYHRH CDEVGFNAEE AHNIVKECVD GVLGGEDYNH NNINQWTASI VEQSLTHLVK LGKAYKYIVT CAVVQKSAYG FHTASSCFWD TTSDGTCTVR WENRTMNCIV NVFAIAIVL |
DYNLT3 belongs to a subclass of dynein light chains. The DYNLT3 protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. DYNLT3 functions as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex which are believed to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DYNLT3 may also work independently of dynein as a transcriptional modulator. DYNLT3 is required for the effective progression through mitosis.
DYNLT3 Human Recombinant produced in E. coli is a single polypeptide chain containing 139 amino acids (1-116) and having a molecular mass of 15.5 kDa.DYNLT3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis. |
| NCBI Summary: | This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010] |
| UniProt Code: | P51808 |
| NCBI GenInfo Identifier: | 5730087 |
| NCBI Gene ID: | 6990 |
| NCBI Accession: | NP_006511.1 |
| UniProt Secondary Accession: | P51808,Q6ICS3, |
| UniProt Related Accession: | P51808 |
| Molecular Weight: | 12 |
| NCBI Full Name: | dynein light chain Tctex-type 3 |
| NCBI Synonym Full Names: | dynein light chain Tctex-type 3 |
| NCBI Official Symbol: | DYNLT3�� |
| NCBI Official Synonym Symbols: | RP3; TCTE1L; TCTEX1L�� |
| NCBI Protein Information: | dynein light chain Tctex-type 3 |
| UniProt Protein Name: | Dynein light chain Tctex-type 3 |
| UniProt Synonym Protein Names: | Protein 91/23; T-complex-associated testis-expressed 1-like |
| UniProt Gene Name: | DYNLT3�� |
