Description
| Product Name: | Human DYNLL2 Recombinant Protein |
| Product Code: | RPPB3380 |
| Size: | 20µg |
| Species: | Human |
| Target: | DYNLL2 |
| Synonyms: | Dynein light chain LC8-type 2, DNCL1B, Dlc2, MGC17810, RSPH22, 8kDa dynein light chain b, DLC8b, dynein light chain 2 cytoplasmic, radial spoke 22 homolog. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | DYNLL2 protein solution (1 mg/1ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.2M NaCl and 1mM DTT. |
| Stability: | DYNLL2 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.�� |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG |
Dyneins are multi-subunit, high molecular weight ATPases which cooperate with microtubules to create energy by altering the chemical energy of ATP into the mechanical energy of movement. DYNLL2 is a large protein complex made up of six different subunits and is in charge of a large number of intracellular movements to the minus ends of microtubules. DYNLL2 is an extremely conserved eukaryotic hub protein with dozens of binding partners and numerous roles other than being a subunit of dynein and myosin Va motor proteins.
DYNLL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids (1-89a.a) and having a molecular mass of 12.5kDa.DYNLL2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DYNLL2: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Belongs to the dynein light chain family. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 17q22 Cellular Component: dynein complex; microtubule; centrosome; membrane; plasma membrane; myosin complex; cytosol; nucleus Molecular Function:protein binding; cytoskeletal protein binding; motor activity Biological Process: metabolic process; transport; apoptosis; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based process; synaptic target recognition |
| UniProt Code: | Q96FJ2 |
| NCBI GenInfo Identifier: | 56748850 |
| NCBI Gene ID: | 140735 |
| NCBI Accession: | Q96FJ2.1 |
| UniProt Secondary Accession: | Q96FJ2,B2R5B4, |
| UniProt Related Accession: | Q96FJ2 |
| Molecular Weight: | 10,350 Da |
| NCBI Full Name: | Dynein light chain 2, cytoplasmic |
| NCBI Synonym Full Names: | dynein, light chain, LC8-type 2 |
| NCBI Official Symbol: | DYNLL2�� |
| NCBI Official Synonym Symbols: | Dlc2; DNCL1B; RSPH22�� |
| NCBI Protein Information: | dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; radial spoke 22 homolog |
| UniProt Protein Name: | Dynein light chain 2, cytoplasmic |
| UniProt Synonym Protein Names: | 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DYNLL2�� |
| UniProt Entry Name: | DYL2_HUMAN |
