Description
| Product Name: | Human DUSP26 Recombinant Protein |
| Product Code: | RPPB1600 |
| Size: | 20µg |
| Species: | Human |
| Target: | DUSP26 |
| Synonyms: | Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3, Dual specificity phosphatase 26 (putative). |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The DUSP26 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA |
Dual Specificity Phosphatase 26 (DUSP26) inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DUSP26 also induces activation of MAP kinase p38 and c-Jun N-terminal kinase. DUSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a decrease in its DNA-binding activity.
DUSP26 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (1-211a.a) and having a molecular mass of 26.3kDa.DUSP26 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 8p12Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleusMolecular Function: protein binding; p53 binding; phosphoserine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activityBiological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q9BV47 |
| NCBI GenInfo Identifier: | 74752374 |
| NCBI Gene ID: | 78986 |
| NCBI Accession: | Q9BV47.1 |
| UniProt Secondary Accession: | Q9BV47,Q9BTW0, D3DSV8 |
| UniProt Related Accession: | Q9BV47 |
| Molecular Weight: | 23,946 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 26 |
| NCBI Synonym Full Names: | dual specificity phosphatase 26 (putative) |
| NCBI Official Symbol: | DUSP26�� |
| NCBI Official Synonym Symbols: | MKP8; LDP-4; NATA1; SKRP3; DUSP24�� |
| NCBI Protein Information: | dual specificity protein phosphatase 26; DSP-4; MKP-8; MAP kinase phosphatase 8; dual specificity phosphatase SKRP3; dual-specificity phosphatase SKRP3; mitogen-activated protein kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; low-molecular-mass dual-specificity phosphatase 4 |
| UniProt Protein Name: | Dual specificity protein phosphatase 26 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP26�� |
| UniProt Entry Name: | DUS26_HUMAN |
