Description
| Product Name: | Human DENR Recombinant Protein |
| Product Code: | RPPB3348 |
| Size: | 20µg |
| Species: | Human |
| Target: | DENR |
| Synonyms: | Density-regulated protein, DRP, Protein DRP1, Smooth muscle cell-associated protein 3, SMAP-3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DENR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK |
DENR takes part in the translation of target mRNAs by scanning and recognizing the initiation codon. DENR protein is involved in the intonation of the translational profile of a subset of cancer-related mRNAs when engaged to the translational initiation complex by the oncogene MCTS1.
DENR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 218 amino acids (1-198) and having a molecular mass of 24.3 kDa.The DENR is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DENR: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays a role in the modulation of the translational profile of a subset of cancer- related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. Belongs to the DENR family. |
| UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 12q24.31 Molecular Function:protein binding; translation initiation factor activity Biological Process: ribosome disassembly; formation of translation preinitiation complex |
| NCBI Summary: | This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43583 |
| NCBI GenInfo Identifier: | 13637727 |
| NCBI Gene ID: | 8562 |
| NCBI Accession: | O43583.2 |
| UniProt Secondary Accession: | O43583,Q9H3U6, Q9UKZ0, |
| UniProt Related Accession: | O43583 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Density-regulated protein |
| NCBI Synonym Full Names: | density-regulated protein |
| NCBI Official Symbol: | DENR�� |
| NCBI Official Synonym Symbols: | DRP; DRP1; SMAP-3�� |
| NCBI Protein Information: | density-regulated protein; smooth muscle cell associated protein-3; smooth muscle cell-associated protein 3 |
| UniProt Protein Name: | Density-regulated protein |
| UniProt Synonym Protein Names: | Protein DRP1; Smooth muscle cell-associated protein 3; SMAP-3 |
| Protein Family: | Density-regulated protein |
| UniProt Gene Name: | DENR�� |
| UniProt Entry Name: | DENR_HUMAN |
